Effect of clofibrate on the CoA thioester profile in rat liver
| Autor: | Michael R. Ball, K.A. Gumaa, Patricia McLean |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
Citric Acid Cycle Biophysics Propionyl-CoA carboxylase Biochemistry chemistry.chemical_compound Methylcrotonyl-CoA carboxylase Acetoacetyl-CoA medicine Animals Coenzyme A Succinyl-CoA Clofibrate Molecular Biology Beta oxidation Acetyl-CoA Cell Biology Dietary Fats Rats Malonyl-CoA Liver chemistry Acyl Coenzyme A Energy Metabolism Mitochondrial ADP ATP Translocases Oxidation-Reduction medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 87:489-496 |
| ISSN: | 0006-291X |
| Popis: | Acute and chronic treatment with clofibrate increased the total CoA content of rat liver and altered the profile of the various CoA thioesters. There resulted a 2–3 fold increase in the contents of long chain acyl CoA, acetyl CoA and free CoA, contrasting with significant decreases found in succinyl CoA, malonyl CoA and acetoacetyl CoA contents. It is postulated that the known increase in fatty acid binding protein and/or the increased extramitochondrial β-oxidation of fat by an increased peroxisomal population may direct the compartmentation and metabolic fate of fatty acids and their CoA derivatives following clofibrate treatment. |
| Databáze: | OpenAIRE |
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