EEG-directed connectivity from posterior brain regions is decreased in dementia with Lewy bodies: a comparison with Alzheimer's disease and controls
| Autor: | Alida A. Gouw, Elisabeth C.W. van Straaten, Iris E. C. Sommer, Hanneke de Waal, Edwin van Dellen, Cornelis J. Stam, Meenakshi Dauwan, Wiesje M. van der Flier, Afina W. Lemstra, Lotte van Boxtel, Philip Scheltens |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Amsterdam Neuroscience - Neurodegeneration, Neurology, Epidemiology and Data Science |
| Rok vydání: | 2016 |
| Předmět: |
Male
Aging Entropy Disease Electroencephalography 0302 clinical medicine Neural Pathways Diagnosis Non-U.S. Gov't Lewy Body Disease/diagnosis Clinical syndrome medicine.diagnostic_test Research Support Non-U.S. Gov't General Neuroscience 05 social sciences Brain Middle Aged Alpha band Female Psychology Lewy Body Disease Alzheimer Disease/diagnosis Rest Research Support Neural Pathways/physiopathology behavioral disciplines and activities 050105 experimental psychology Diagnosis Differential Age and gender 03 medical and health sciences Beta band Alzheimer Disease mental disorders Journal Article medicine Humans Comparative Study 0501 psychology and cognitive sciences In patient Aged Brain/physiopathology Dementia with Lewy bodies Rest/physiology medicine.disease nervous system diseases Differential Neurology (clinical) Geriatrics and Gerontology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging, 41, 122-129. ELSEVIER SCIENCE INC Dauwan, M, van Dellen, E, van Boxtel, L, van Straaten, E C W, de Waal, H, Lemstra, A W, Gouw, A, van der Flier, W M, Scheltens, P, Sommer, I E & Stam, C J 2016, ' EEG-directed connectivity from posterior brain regions is decreased in dementia with Lewy bodies: a comparison with Alzheimer's disease and controls ', Neurobiology of Aging, vol. 41, pp. 122-129 . https://doi.org/10.1016/j.neurobiolaging.2016.02.017 Neurobiology of Aging, 41, 122-129. Elsevier Inc. Neurobiology of Aging, 41, 122. Elsevier Inc. |
| ISSN: | 0197-4580 |
| Popis: | Directed information flow between brain regions might be disrupted in dementia with Lewy bodies (DLB) and relate to the clinical syndrome of DLB. To investigate this hypothesis, resting-state electroencephalography recordings were obtained in patients with probable DLB and Alzheimer's disease (AD), and controls (N = 66 per group, matched for age and gender). Phase transfer entropy was used to measure directed connectivity in the groups for the theta, alpha, and beta frequency band. A posterior-to-anterior phase transfer entropy gradient, with occipital channels driving the frontal channels, was found in controls in all frequency bands. This posterior-to-anterior gradient was largely lost in DLB in the alpha band (p < 0.05). In the beta band, posterior brain regions were less driving in information flow in AD than in DLB and controls. In conclusion, the common posterior-to-anterior pattern of directed connectivity in controls is disturbed in DLB patients in the alpha band, and in AD patients in the beta band. Disrupted alpha band–directed connectivity may underlie the clinical syndrome of DLB and differentiate between DLB and AD. |
| Databáze: | OpenAIRE |
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