Genetic and Pharmacological Discovery for Alzheimer’s Disease Using Caenorhabditis elegans
| Autor: | Edward F Griffin, Guy A. Caldwell, Kim A. Caldwell |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physiology Cognitive Neuroscience tau Proteins Disease Biochemistry 03 medical and health sciences 0302 clinical medicine Human disease Alzheimer Disease RNA interference Drug Discovery medicine Animals Humans Caenorhabditis elegans Organism Amyloid beta-Peptides biology Neurodegeneration Cell Biology General Medicine medicine.disease biology.organism_classification Pharmacogenomic Testing Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neuroscience 030217 neurology & neurosurgery Neuroanatomy |
| Zdroj: | ACS Chemical Neuroscience. 8:2596-2606 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.7b00361 |
| Popis: | The societal burden presented by Alzheimer's disease warrants both innovative and expedient means by which its underlying molecular causes can be both identified and mechanistically exploited to discern novel therapeutic targets and strategies. The conserved characteristics, defined neuroanatomy, and advanced technological application of Caenorhabditis elegans render this metazoan an unmatched tool for probing neurotoxic factors. In addition, its short lifespan and importance in the field of aging make it an ideal organism for modeling age-related neurodegenerative disease. As such, this nematode system has demonstrated its value in predicting functional modifiers of human neurodegenerative disorders. Here, we review how C. elegans has been utilized to model Alzheimer's disease. Specifically, we present how the causative neurotoxic peptides, amyloid-β and tau, contribute to disease-like neurodegeneration in C. elegans and how they translate to human disease. Furthermore, we describe how a variety of transgenic animal strains, each with distinct utility, have been used to identify both genetic and pharmacological modifiers of toxicity in C. elegans. As technological advances improve the prospects for intervention, the rapidity, unparalleled accuracy, and scale that C. elegans offers researchers for defining functional modifiers of neurodegeneration should speed the discovery of improved therapies for Alzheimer's disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|