N-acetyl-β-hexosaminidase in chronic tonsillitis and tonsillar hypertrophy
| Autor: | Anna Niemcunowicz-Janica, Sławomir Dariusz Szajda, Katarzyna Krajewska, Alina Minarowska, Mariola Zagor, Marcin Bierć, Krzysztof Zwierz, Anna Jackowska, Justyna Marciniak, Małgorzata Knaś, Łukasz Minarowski, Tomasz Jackowski, Agnieszka Zaniewska |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Palatine Tonsil Muscle hypertrophy Young Adult stomatognathic system N acetyl β otorhinolaryngologic diseases Humans Medicine Hexosaminidase In patient Tonsillar hypertrophy Child Aged business.industry Chronic tonsillitis Age Factors Hypertrophy Middle Aged respiratory system beta-N-Acetylhexosaminidases carbohydrates (lipids) Tonsillitis stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Child Preschool Healthy individuals Tonsil Chronic Disease Immunology Female business Biomarkers |
| Zdroj: | Otolaryngologia Polska. 67:204-208 |
| ISSN: | 0030-6657 |
| Popis: | Background: The concentration and specific activity of N-acetyl-β-hexosaminidase (HEX) in palatine tonsils with chronic tonsillitis and tonsillar hypertrophy give insight in tonsillar tissue remodeling and constitute a potential marker for diagnosis and treatment of chronic tonsillitis and tonsillar hypertrophy. Aim: Determining the concentration and specific activity of N-acetyl-β-hexosaminidase in palatine tonsils with hypertrophy and chronic tonsillitis. Methods: HEX activity was analyzed by the method of Marciniak et al. with p-nitrophenyl N-acetyl-β-glucosaminepyranoside as a substrate. Results: The concentration and specific activity of HEX in palatine tonsils in patients with tonsillar hypertrophy and chronic tonsillitis both in childhood and adulthood significantly increase in comparison to healthy individuals. Conclusions: Our data demonstrate the presence of HEX in palatine tonsils and indicate on significant increase of its concentration and specific activity. Based on content and specific HEX activity we suggest that tonsils with hypertrophy and chronic tonsillitis should be treated as identical unit irrespectively of age. |
| Databáze: | OpenAIRE |
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