THE MECHANISM OF STIMFORTE ACTION ON HERPESVIRUS INFECTION
| Autor: | S. S. Grigorian, E. I. Isaeva, A. A. Terentyev, A. A. Balakina, V. L. Andronova, D. G. Mal’dov, Galegov Ga, A. V. Ilyichev |
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| Rok vydání: | 2018 |
| Předmět: |
Gene Expression Regulation
Viral 0301 basic medicine Drug medicine.medical_treatment media_common.quotation_subject Herpesvirus 1 Human Biology Virus Replication medicine.disease_cause Granzymes Microbiology Interferon-gamma Mice 03 medical and health sciences Interferon Virology medicine Animals Humans Organic Chemicals Lung media_common Innate immune system Protease Brain Herpesviridae Infections Interferon-beta General Medicine 030112 virology Killer Cells Natural Granzyme B Infectious Diseases Herpes simplex virus medicine.drug |
| Zdroj: | Problems of Virology. 63:218-223 |
| ISSN: | 2411-2097 0507-4088 |
| Popis: | Increased protease activity and a significant amount of granzyme B were observed in in organs of mice infected with acute herpes simplex virus HSV-1 with the introduction of Stimforte (100 or 250 µg/mouse). Thus, this drug activates killer cells, which play an extremely important role in the suppression of HSV-1 infection. Although the administration of Stimforte (100 μg/mouse) to intact mice results in the activation of IFN-β production and does not activate the production of IFN-λ, Stimforte administration to animals infected with HSV-1 reduces production of IFN-β in serum, brain and lungs, whereas the production of IFN-λ considerably increases as the result of administration of 100 μg/mouse of Stimforte. |
| Databáze: | OpenAIRE |
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