Characteristics of superinfections during treatment with tigecycline
| Autor: | Evangelia D Platsouka, Zoi Roussou, Asimina Maguina, Kyriakos Ntorlis, Maria Katsiari, Ioannis Nteves |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine 030106 microbiology Minocycline Tigecycline medicine.disease_cause Microbiology 03 medical and health sciences 0302 clinical medicine Risk Factors Drug Resistance Bacterial Gram-Negative Bacteria medicine Humans Pharmacology (medical) 030212 general & internal medicine Pathogen Aged Pharmacology Cross Infection biology Pseudomonas aeruginosa Providencia stuartii Middle Aged biology.organism_classification Proteus mirabilis Anti-Bacterial Agents Stenotrophomonas maltophilia Infectious Diseases Oncology Superinfection Female Gram-Negative Bacterial Infections Bacteria medicine.drug |
| Zdroj: | Journal of Chemotherapy. 28:110-115 |
| ISSN: | 1973-9478 1120-009X |
| DOI: | 10.1080/1120009x.2015.1118184 |
| Popis: | Tigecycline has a broad-spectrum in vitro activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant (MDR) strains. However, some Gram-negative bacteria are intrinsically resistant or have reduced susceptibility to tigecycline. We performed a prospective, observational study of 43 patients who received tigecycline as the treatment for serious infections due to MDR Gram-negative microorganisms, to evaluate superinfections. In 60.5% of our patients, tigecycline-resistant (T-R) Gram-negative microorganisms were isolated, representing superinfection in 37.2% and colonization in 23.5%. Pseudomonas aeruginosa was the predominant pathogen (48.4%) followed by Providencia stuartii, Proteus mirabilis and Stenotrophomonas maltophilia. Median time elapsed between tigecycline prescription and isolation of T-R pathogens was 7 days. The 16 superinfections consisted of ventilator-associated pneumonias (43.75%), catheter-related bloodstream infections (37.5%), intra-abdominal infections (12.5%) and urinary tract infection (6.25%). Attributed mortality to superinfections was 31.25%. The comparison of various potential risk factors for isolation of T-R microorganisms did not reveal statistically significant results. |
| Databáze: | OpenAIRE |
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