Determinants of survival in patients with congestive cardiomyopathy: quantitative morphologic findings and left ventricular hemodynamics
| Autor: | Kübler W, H. Zebe, Joachim Manthey, F Schwarz, Gerhard Mall, E Schmitzer, H Scheurlen |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Systole Cardiomyopathy Diastole Hemodynamics Physiology (medical) Internal medicine Biopsy Humans Medicine cardiovascular diseases Heart Failure Ejection fraction medicine.diagnostic_test business.industry Myocardium Germany West Stroke Volume Stroke volume Middle Aged Prognosis medicine.disease Heart catheterization cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 70:923-928 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.70.6.923 |
| Popis: | We analyzed data from 68 consecutive patients with congestive cardiomyopathy to evaluate the prognostic significance of quantitative morphologic findings in left ventricular myocardium as compared with the prognostic significance of left ventricular hemodynamics. Left ventricular endomyocardial biopsy specimens were obtained from all patients during diagnostic heart catheterization. Myocardial fiber diameter, volume fraction of interstitial fibrosis, and intracellular volume fraction of myofibrils were determined by light-microscopic morphometry. All patients had normal coronary arteriograms, but reduced left ventricular ejection fractions. There were 23 deaths during a mean follow-up period of 1124 days. Multivariate regression analysis (Cox model) revealed that left ventricular ejection fraction (p less than .00001) and left ventricular systolic pressure (p less than .01), but not morphometric findings in biopsy specimens, were independent predictors of cardiac death. Thus, morphologic findings in the left ventricular myocardium do not contribute significantly to the prognostic evaluation in patients with congestive cardiomyopathy studied by hemodynamic and angiographic methods. |
| Databáze: | OpenAIRE |
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