Influence of diameter of fiber membrane scaffolds on the biocompatibility of hPDL mesenchymal stromal cells
| Autor: | Febe Carolina Vázquez-Vázquez, Marco Antonio Alvarez-Perez, Amaury Pozos-Guillén, José Luis Suárez-Franco, Octavio Alvarez-Fregoso, Juan José Montesinos |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Scaffold Materials science Biocompatibility Adolescent Cell Survival Periodontal Ligament Surface Properties Polyesters Nanofibers Biocompatible Materials 02 engineering and technology Microscopy Atomic Force 03 medical and health sciences 0302 clinical medicine stomatognathic system Tissue engineering Materials Testing Cell Adhesion Periodontal fiber Humans Bicuspid Fiber General Dentistry Cell Proliferation Tissue Engineering Tissue Scaffolds technology industry and agriculture Mesenchymal Stem Cells 030206 dentistry Adhesion respiratory system equipment and supplies 021001 nanoscience & nanotechnology Polyester Nanofiber Ceramics and Composites Microscopy Electron Scanning lipids (amino acids peptides and proteins) 0210 nano-technology Biomedical engineering |
| Zdroj: | Dental materials journal. 37(3) |
| ISSN: | 1881-1361 |
| Popis: | This study evaluated the influence in the biocompatibility of human periodontal ligament (hPDL) mesenchymal stromal cell onto poly lactic-acid (PLA) films and PLA fiber membrane. Fiber scaffold was prepared via air jet spinning (AJS) from PLA solutions (6, 7, and 10%) and analyzed using SEM, AFM and FTIR. Biocompatibility was evaluated by adhesion, proliferation and cell-material interaction. PLA film exhibited a smooth and homogenously surface topography in comparison with random orientation of PLA fiber with roughness structure where diameter size depends on PLA solution. Moreover, cell adhesion; proliferation and cell-material interaction has the best respond on random orientation nanofiber of 10, followed by 7, and 6% of PLA in comparison with PLA films. It could be concluded that AJS is an attractive alternative technique for manufacture fiber scaffolds with a tunable random orientation geometry of fibers that allow to produce interconnected porous formed by nanometric fiber diameter structures that could be a potential scaffold for periodontal tissue engineering applications. |
| Databáze: | OpenAIRE |
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