p2PSA for predicting biochemical recurrence of prostate cancer earlier than total prostate-specific antigen after radical prostatectomy: an observational prospective cohort study
| Autor: | Lucia Motta, Giorgio Guazzoni, L. Domanico, Marta Monari, Giulio M. Mondellini, Giovanni Lughezzani, Marco Paciotti, Vittorio Bini, Davide Maffei, Rodolfo Hurle, Alberto Saita, Massimo Lazzeri, Giuliana Lista, Vittorio Fasulo, Nicolò Buffi, Ferruccio Ceriotti, Paolo Casale |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Biochemical recurrence medicine.medical_specialty Laparoscopic radical prostatectomy Urology medicine.medical_treatment Population Cohort Studies Prostate cancer Predictive Value of Tests Biomarkers Tumor medicine Humans Prospective Studies Prospective cohort study education Aged Prostatectomy education.field_of_study business.industry Margins of Excision Prostatic Neoplasms Middle Aged Prostate-Specific Antigen Reference Standards medicine.disease Prostate-specific antigen Nephrology Predictive value of tests Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Minerva Urologica e Nefrologica. 71 |
| ISSN: | 1827-1758 0393-2249 |
| DOI: | 10.23736/s0393-2249.19.03279-x |
| Popis: | BACKGROUND There is an unmet clinical need for more biochemical specific tests that may detect clinically significant recurrent PCa at an early stage after radical prostatectomy (RP). Our purpose is to test the hypothesis that p2PSA (Index test) detects prostate cancer relapse (BCR) earlier than the current Reference Standard Test (total prostate-specific antigen [tPSA]) in patients who underwent RP for localized PCa. METHODS This is an observational, prospective, cohort, follow-up study in patients subjected to RALP (robotic assisted laparoscopic radical prostatectomy) for clinically localized PCa from January 2013 to July 2013 at a high-volume Institution (450 average RP/year). A blood sample, for tPSA and p2PSA, was prospectively drawn after 3, 6, and 12 months and then every 6 months during the following two years. The primary outcome is to determine whether or not kinetics in rising of p2PSA significantly anticipates the tPSA kinetics. Exploratory data analysis was used to identify relationship between different variables. RESULTS Over 134 patients 20 BCRs were detected according to tPSA cut-off. Five patients showed a contemporary increase of tPSA and p2PSA, 11 presented a p2PSA increase earlier than tPSA increase (13.9 months ±9.7). In four patients, the increase of PSA was not associated with a p2PSA>0.8 pg/mL. The correlation between tPSA and p2PSA according to Sperman's rho coefficient was statistically significant at 3, 6, 18 and 30 months: 0.416 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|