Fetal growth restriction in hypothyroidism is associated with changes in proliferative activity, apoptosis and vascularisation of the placenta

Autor: Natália de Melo Ocarino, Jankerle Neves Boeloni, E.F. Nascimento, Philipe Pimenta Nunes, Paula N Vidigal, Daniele D Galvão, Juneo Freitas Silva, Rogéria Serakides
Rok vydání: 2011
Předmět:
Vascular Endothelial Growth Factor A
Angiogenesis
Placenta
Uterus
Apoptosis
Reproductive technology
chemistry.chemical_compound
Endocrinology
Pregnancy
reproductive and urinary physiology
Adenosine Triphosphatases
education.field_of_study
Fetal Growth Retardation
Immunohistochemistry
Trophoblasts
Vascular endothelial growth factor
DNA-Binding Proteins
medicine.anatomical_structure
Fetal Weight
embryonic structures
Gestation
Female
Glycogen
Biotechnology
medicine.medical_specialty
Population
Down-Regulation
Neovascularization
Physiologic
Gestational Age
Biology
Hypothyroidism
Internal medicine
Genetics
medicine
Animals
education
Molecular Biology
Fetal Death
Cell Proliferation
Fetus
Minichromosome Maintenance Complex Component 7
Rats
Disease Models
Animal
Reproductive Medicine
chemistry
Propylthiouracil
Animal Science and Zoology
Biomarkers
Developmental Biology
Zdroj: Reproduction, fertility, and development. 24(7)
ISSN: 1031-3613
Popis: The objective of this study was to evaluate fetal weight, histomorphometric changes and proliferative activity, apoptosis and angiogenesis of the placenta in rats with hypothyroidism. Thirty-six adult female rats were divided into two groups with 18 animals each: control and hypothyroidism. Hypothyroidism was induced by daily administration of propylthiouracil (1 mg/animal). The administration began five days before becoming pregnant and the animals were sacrificed at 14 or 19 days of gestation. The control group received a placebo. The number and weight of fetuses and the rate of fetal death was determined, as well as the morphometric characteristics, the immunohistochemical expression of cell division control protein 47 (CDC)-47 and vascular endothelial growth factor (VEGF) and the number of apoptotic cells in the placental disk. The data were analysed by Mann–Whitney U test. Hypothyroidism reduced the weight of fetuses and of the uterus and placenta (P
Databáze: OpenAIRE
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