Increased procollagen type III peptide in serum of rabbits exposed to diesel engine exhaust
| Autor: | Takako Kanoh, Takahito Suzuki |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Time Factors Health Toxicology and Mutagenesis Nitrogen Dioxide Radioimmunoassay Connective tissue Peptide Toxicology Nitric Oxide Blood serum Fibrosis medicine Animals Particle Size Lung Vehicle Emissions chemistry.chemical_classification Air Pollutants medicine.diagnostic_test biology Chemistry Scleroprotein General Medicine respiratory system medicine.disease Pollution Molecular biology Peptide Fragments Procollagen peptidase Bronchoalveolar lavage medicine.anatomical_structure Petroleum Immunology biology.protein Collagen Rabbits Elastin Bronchoalveolar Lavage Fluid Fuel Oils Procollagen |
| Zdroj: | Bulletin of environmental contamination and toxicology. 44(5) |
| ISSN: | 0007-4861 |
| Popis: | Lung connective tissue is composed of collagen, elastin and proteoglycans. Collagen is the most abundant protein, comprising approximately 11% of normal adult lung and it has been provided at least five polymorphic types in lung. Collagen-producing cells such as fibroblasts and endothelial cells can synthesize procollagen within the cells. Once procollagen is secreted extracellularly, both amino- and carboxy-terminal peptides of procollagen are cleaved by endopeptidases. These peptides can move from the tissue into the blood stream. Therefore, the released peptides of type III procollagen may reflect the degree of biosynthesis of type III collagen, and increased peptide level in type III collagen, and increased peptide level in serum may suggest inflammation or the beginning of fibrosis. In this work, the authors have studied the changes of procollagen type III peptide (P-III-P) levels in sera and bronchoalveolar lavage fluid (BALF) from rabbits exposed to diesel exhaust in order to find a useful biochemical indicator of the effects of diesel exhaust exposure on human health. |
| Databáze: | OpenAIRE |
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