30-year follow-up study of IgA nephritis in a Southeast Asian population: an evaluation of the Oxford histological classification
| Autor: | Ai Zhen Jin, Marjorie Foo, Yok Mooi Chin, Han Khim Tan, Hwai L. Loh, Puay Hoon Tan, Jason C J Choo, Khuan Yew Chow, Keng-Thye Woo, Cynthia C. Lim, Lina H-L Choong, Choong Meng Chan, Kok Seng Wong |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Population Kidney Glomerulus 030232 urology & nephrology Renal function Mesangial hypercellularity 030204 cardiovascular system & hematology urologic and male genital diseases Southeast asian Gastroenterology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans education Aged Cell Proliferation education.field_of_study Singapore medicine.diagnostic_test business.industry Glomerulosclerosis Focal Segmental Endothelial Cells Glomerulonephritis IGA General Medicine Middle Aged medicine.disease Fibrosis Capillaries Nephrology Cohort Disease Progression Kidney Failure Chronic Female Renal biopsy Atrophy business Nephritis Kidney disease Follow-Up Studies Glomerular Filtration Rate |
| Zdroj: | Clinical nephrology. 86(11) |
| ISSN: | 0301-0430 |
| Popis: | BACKGROUND In 1985 we reported that 11% of a cohort of 151 patients with IgA nephritis (IgAN) had developed end-stage renal disease (ESRD) after a follow-up period of 5 years. 15 years later, 35% had developed ESRD. METHODS We retrieved 125 stored renal biopsy paraffin blocks of the original cohort. From these, 102 patients were included in the present study and scored according to the Oxford classification as 21 specimens with less than 8 glomeruli were excluded and in 2 others, tissue samples were too tiny for a re-block. ESRD was ascertained by linking the study cohort to the Singapore Renal Registry at the National Registry of Diseases Office. RESULTS Renal survival curves for each of the Oxford MEST lesions: endocapillary proliferation (E) (p |
| Databáze: | OpenAIRE |
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