Expression of class I and II major histocompatibility complex antigens in Wilms' tumour and normal developing human kidney
| Autor: | G.M Borthwick, G.M Stirrat, C.H Holmes, S.J Davis, L Hughes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1988 |
| Předmět: |
Adult
Cancer Research medicine.drug_class Mesenchyme Kidney Glomerulus Vimentin Gestational Age Biology Monoclonal antibody Major histocompatibility complex Kidney Wilms Tumor Fetus Antigen medicine Humans Child Histocompatibility Antigens Class I Histocompatibility Antigens Class II Wilms' tumor medicine.disease Kidney Neoplasms Histocompatibility medicine.anatomical_structure Kidney Tubules Oncology Immunology Cancer research biology.protein Keratins Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The Wilms' tumour is a solid childhood tumour of the kidney, consisting of blastema, tubules and mesenchyme. Embryonic tumours, such as Wilms', may arise as a result of a developmental disturbance in differentiation. The expression of class I and II major histocompatibility complex (MHC) antigens was investigated on 6 Wilms' tumours and related to that in the developing human kidney in this immunohistological study, using a panel of monoclonal antibodies. The Wilms' tumour blastemal cells were class I MHC antigen negative, but differentiated structures were positive. Class II MHC antigens were not observed in Wilms' tumours. In the developing human kidney class I MHC antigen expression was observed on glomeruli from 8 weeks and on tubules from 13 weeks gestational age. Class II MHC antigen expression was observed on glomeruli from 11 weeks and on tubules from 13 weeks gestation. These results suggest that the blastemal cells within the Wilms' tumour may reflect an early stage of development with respect to the expression of MHC antigens. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|