The pyrethroid λ-cyhalothrin induces biochemical, genotoxic, and physiological alterations in the teleost Prochilodus lineatus
| Autor: | Cláudia B.R. Martinez, Carlos Eduardo Delfino Vieira |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gill Erythrocytes Environmental Engineering Health Toxicology and Mutagenesis Context (language use) 010501 environmental sciences medicine.disease_cause 01 natural sciences Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Nitriles Pyrethrins medicine Animals Environmental Chemistry Biotransformation 0105 earth and related environmental sciences Pyrethroid Public Health Environmental and Occupational Health General Medicine General Chemistry Pollution Fungicides Industrial Cyhalothrin Oxidative Stress 030104 developmental biology Liver chemistry Biochemistry Osmoregulation Lipid Peroxidation Characiformes Biomarkers Water Pollutants Chemical Oxidative stress Genotoxicity DNA Damage |
| Zdroj: | Chemosphere. 210:958-967 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/j.chemosphere.2018.07.115 |
| Popis: | The λ-cyhalothrin (CL) is a globally used pyrethroid insecticide that has been detected in different water bodies worldwide. However, studies on the effects of CL on freshwater fishes are still incipient. In this context, we evaluated the acute effects of a commercial formulation containing CL (Karate Zeon® CS 50) in juveniles of the teleost Prochilodus lineatus exposed for 96 h to four concentrations of the active ingredient (5, 50, 250 and 500 ng.L−1). Biochemical, physiological, and genotoxic biomarkers were evaluated in different organs of the fish. Exposure to CL induced significant changes in the enzymatic profiles of P. lineatus, with specific alterations in biotransformation enzymes and antioxidant defence in different tissues. Lipid peroxidation was observed in fish gills and kidney. Increases in esterases were observed in the liver of fish exposed to all CL concentrations evaluated, whereas acetylcholinesterase activity decreased in the muscles of fish at all concentrations. CL also promoted osmoregulatory disorders, with decreases in calcium and magnesium gill ATPases, with consequent hypocalcaemia, in addition an increase in sodium-potassium ATPase activity was observed in the gills of fish exposed to the highest CL concentration, probably in order to compensate a reduction in plasma sodium. Besides, increases in DNA damage were observed in the erythrocytes of fish exposed to all CL concentrations. Thus, despite the low CL concentrations and the short exposure time, this pyrethroid caused hematological adjustments, oxidative stress, osmoregulatory disorders, and DNA damage in P. lineatus, showing that the species is highly sensitive to the deleterious effects of CL. |
| Databáze: | OpenAIRE |
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