Microglia in the developing brain: from immunity to behaviour
| Autor: | Timm Schlegelmilch, Katrin Henke, Francesca Peri |
|---|---|
| Přispěvatelé: | University of Zurich, Peri, Francesca |
| Rok vydání: | 2010 |
| Předmět: |
Neurons
0303 health sciences Microglia Behavior Animal General Neuroscience 2800 General Neuroscience Brain Biology 10124 Institute of Molecular Life Sciences 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure nervous system Immunity medicine 570 Life sciences biology Animals Humans Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Current Opinion in Neurobiology |
| ISSN: | 1873-6882 |
| Popis: | For decades, microglia, the resident macrophages of the brain, have been recognized mostly for their role in several, if not all, pathologies affecting the brain. However, several studies under physiological conditions demonstrate that microglial function is indispensable also in the healthy brain. Indeed, microglia implement key functions already during development, such as the clearance of the huge amount of neurons that are produced in large excess in the embryo and later die of apoptosis. Beside these classical functions, however, novel roles are emerging that strikingly link microglia with higher order brain functions and show that these cells can ultimately influence behaviour. Therefore a detailed understanding of microglia under physiological conditions may open unprecedented perspectives in the prevention and treatment of neuropsychiatric diseases. |
| Databáze: | OpenAIRE |
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