Evaluation of a Phenobarbital-Based Protocol for Severe Alcohol Withdrawal in Critically Ill Patients
| Autor: | Jeremy R. DeGrado, Kevin M Dube, Mary P Kovacevic, Paul M. Szumita, Melanie Goodberlet |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Protocol (science) medicine.medical_specialty Neurology Critically ill business.industry Alcohol Original Articles Pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine Pharmacology (medical) Phenobarbital 030212 general & internal medicine Intensive care medicine business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Hosp Pharm |
| ISSN: | 1945-1253 0018-5787 |
| Popis: | Background: Phenobarbital offers several possible advantages to benzodiazepines including a longer half-life and anti-glutamate activity, and is an alternative for the treatment of alcohol withdrawal. The objective of this analysis was to evaluate the safety and efficacy of a phenobarbital protocol for alcohol withdrawal newly implemented at our institution. Methods: This was a single-center, retrospective analysis of adult patients admitted to the medical/surgical/burn/trauma intensive care unit (ICU) with or at risk of severe alcohol withdrawal. Patients who were admitted prior to guideline implementation and received scheduled benzodiazepines (PRE) were compared to those who received phenobarbital post guideline update (POST). The primary outcome was ICU length of stay (LOS). Results: Upon analysis, 68 patients in the PRE and 64 patients in the POST were identified for inclusion. The median APACHE II score was significantly higher in the POST (4.5 [3:9] vs 10 [5:13], P |
| Databáze: | OpenAIRE |
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