Cytogenetic profile of adult AML patients in Turkey: a single center study with comprehensive comparison with literature

Autor: Cirakoglu, Ayse, Dilhan Kuru, Rahiye, Yilmaz, Sukriye, Deviren, Ayhan, Ongoren, Seniz, Firat Yalniz, Fevzi, Keskin, Dilek, Emre Eskazan, Ahmet, Salihoglu, Ayse, Cem Ar, Muhlis, Sahin, Serdar, Aydin, Yildiz, Hacihanefioglu, Seniha, Baslar, Zafer, Soysal, Teoman, Tarkan Arguden, Yelda
Rok vydání: 2022
Předmět:
Zdroj: African Health Sciences; Vol. 22 No. 3 (2022); 183-191
ISSN: 1729-0503
1680-6905
Popis: Background: Cytogenetic findings are important prognostic factors in acute myeloid leukemia. Large systematic data about chromosomal characteristics of Turkish AML patients have not been reported to date. Objectives: The karyotypic profiles of 157 adult AML patients were evaluated retrospectively and compared with other reports from different populations. Methods: Cytogenetics analyses were performed on bone marrow samples using G-banding. Patients were categorized according to their cytogenetic results into four groups with the addition of a normal karyotyped group to the favorable, intermediate and adverse groups of European Leukemia Network. Results: Cytogenetic analyses were carried out successfully in 138 patients (88%). Abnormal karyotypes were found in 79 (57.2%) patients of which 13 (9.4%) were in favorable, 37 (26.8%) in intermediate and 29 (21%) in adverse groups. t(8;21) (5%) was the most common favorable abnormality while monosomal karyotypes (15.9%) in adverse group. Conclusion: This single center study is the most comprehensive study about the cytogenetic profile of acute myeloid leukemia in Turkey with comparison of other population-based studies. While there were similarities and differences with different publications, our results did not show a marked tendency to the findings of any specific geographic region. Keywords: Acute myeloid leukemia; cytogenetics; chromosomal abnormalities; adult.
Databáze: OpenAIRE
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