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Background: Hematological reference ranges are important in clinical and diagnostic management for the assessment of health and disease conditions. Hematological reference intervals are better to be established based on sex and age differences as these are among the main factors affecting them. Objective: The aim of this study was to establish hematological reference intervals among adolescents aged, 12-17 years in Mekelle, Tigrai, and Northern Ethiopia, 2019. Study area: conducted in Mekelle city Study design and period: using a cross sectional study design conducted from December 2018 to May 2019 G.C. Method: A community-based cross-sectional study was conducted in 249 adolescents aged 12-17 years from December 2018 to May 2019. About 4ml of blood sample was collected using vacutainer tube containing di-potassium Ethylenediamine tetra-acetic acid. Hematological parameters were measured by Sysmex KX-21N hematology analyzer (Sysmex Corporation Kobe, Japan). The data were entered and analyzed by SPSS version 23 statistical software. The 97.5th percentile and 2.5th percentile were the upper and lower reference limit for the study population. Result: A total of 249 adolescents consisting of 122 (49%) males and 127 (51%) females with the median age of 15.31 (range 12 to 17) years were recruited. The median, mean and 95% percentile ranges of hematological values were determined. The 95% RI values were: Red blood cells (1012/Liter), 4.6-5.9 (Males) and 4.28-5.75 (Females); White blood cells (109/Liter), 2.9-9.6 (Males) and 3.4-10.2 (Females); Hemoglobin (g/dl), 12.6-17.6 (Males) and 12-15.4 (Females); Platelets(109/Liter), 138-364 (Males) and 150.6-461.8 (Females). Almost all of the hematological parameters showed significant differences (p |
