Leishmania treatment and prevention: Natural and synthesized drugs
| Autor: | Alaa El-Din A. Bekhit, Adnan A. Bekhit, Amin Shavandi, Eman J. El-Agroudy, Aliaa Helmy, Tamer M. Ibrahim |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antiprotozoal Agents Pharmacology 03 medical and health sciences Structure-Activity Relationship Antileishmanial targets Vaccination trials Drug Discovery medicine Animals Humans Leishmaniasis Leishmania Biological Products biology Dose-Response Relationship Drug Molecular Structure Chemistry Drug discovery Organic Chemistry General Medicine Sciences bio-médicales et agricoles medicine.disease biology.organism_classification Vaccination 030104 developmental biology Synthesized agents Herbal agents |
| Zdroj: | European journal of medicinal chemistry, 160 |
| Popis: | Leishmaniasis affects over 150 million people all over the world, especially in subtropical regions. Currently used antileishmanial synthesized drugs are associated with some drawbacks such as resistance and cytotoxicity, which hamper the chances of treatment. Furthermore, effective leishmanial vaccines are not well developed. Promising chemotherapy, either from natural or synthetic compounds, was or still is the most promising treatment. This review focuses on recent findings in drugs used for the treatment of leishmaniasis including; chemical and natural antileishmanial moieties, different potential targets, as well as various trials of vaccination development. Special emphasis has been paid to the mechanisms of the drugs, their safety and where possible, the structure-activity relationship to enable guided future drug discovery. SCOPUS: re.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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