Angioedema associated with thrombolysis for ischemic stroke: analysis of a case-control study
| Autor: | O. Fain, Denis Sablot, C. Héroum, Thomas Ronzière, M. Gaudron, S. Di Legge, A. Lecluse, Olivier Detante, F. Dumont, S. Marcel, Sonia Alamowitch, D. Gobert, Isabelle Boccon-Gibod, Guillaume Marc, D. Smadja, Michael Obadia, D. Launay, S. Lefèvre, M. Sévin, Laurence Bouillet, Laurent Suissa, Stéphane Gayet, M. B. Vlaicu, Emilie Doche, Clara Vigneron, Nicolas Javaud, Igor Sibon, I. Ion, I. Arnaud, P. Girard‐Madoux |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Bradykinin Angiotensin-Converting Enzyme Inhibitors 030204 cardiovascular system & hematology Brain Ischemia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Risk Factors Internal medicine Internal Medicine medicine Humans Thrombolytic Therapy Angioedema Aged Mechanical ventilation business.industry Case-control study Odds ratio Thrombolysis Stroke 030104 developmental biology chemistry Case-Control Studies Ischemic stroke Cardiology Female France medicine.symptom business Complication |
| Zdroj: | Journal of internal medicineReferences. 286(6) |
| ISSN: | 1365-2796 |
| Popis: | BACKGROUND Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management is discussed. OBJECTIVES To clarify risk factors associated with bradykinin-mediated AE after thrombolysis for acute ischemic stroke. METHODS In a case-control study conducted at a French reference centre for bradykinin angiœdema, patients with thrombolysis for acute ischemic stroke and a diagnosis of bradykinin-mediated angiœdema, were compared to controls treated with thrombolysis treatment without angiœdema. RESULTS Fifty-three thrombolysis-related AE were matched to 106 control subjects. The sites of attacks following thrombolysis for ischemic stroke mainly included tongue (34/53, 64%) and lips (26/53, 49%). The upper airways were involved in 37 (70%) cases. Three patients required mechanical ventilation. Patients with bradykinin-mediated angiœdema were more frequently women [33 (62%) vs. 44 (42%); P = 0.01], had higher frequency of prior ischemic stroke [12 (23%) vs. 9 (8%); P = 0.01], hypertension [46 (87%) vs. 70 (66%); P = 0.005], were more frequently treated with angiotensin-converting enzyme inhibitor [37 (70%) vs. 28 (26%); P |
| Databáze: | OpenAIRE |
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