Preoperative neutrophil-to-lymphocyte, platelet-to-lymphocyte and monocyte-to-lymphocyte ratio as a prognostic factor in non-endometrioid endometrial cancer
| Autor: | Ji Sun Lee, Sang Il Kim, Min Jong Song, Sung Jong Lee, Heekyoung Song, Jimin Cha, Jin Hwi Kim, Min Jin Jeong, Hae Nam Lee, Joo Hee Yoon, Ji Geun Yoo, Dong Choon Park |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Platelets medicine.medical_specialty Multivariate statistics Multivariate analysis Neutrophils Lymphocyte Youden's J statistic chemical and pharmacologic phenomena high risk Gastroenterology Monocytes uterine cancer monocyte-lymphocyte ratio Uterine cancer Internal medicine Republic of Korea platelet-lymphocyte ratio Medicine Humans Lymphocytes neutrophil-lymphocyte ratio Aged Retrospective Studies Aged 80 and over Receiver operating characteristic business.industry Proportional hazards model Endometrial cancer fungi prognostic factors hemic and immune systems General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Blood Cell Count Endometrial Neoplasms medicine.anatomical_structure Treatment Outcome ROC Curve Preoperative Period endometrial cancer systemic inflammation response Female business Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| Popis: | Objective: Evaluate the prognostic value of neutrophil-lymphocyte ratio (NMR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) in patients with non-endometrioid endometrial cancer. Method: Laboratory and clinicopathological data from 118 patients with non-endometrioid endometrial cancer who underwent surgical resection between January 2010 and December 2019 were reviewed. NLR, PLR and MLR were analyzed for correlations with recurrence and survival. The receiver operating characteristic (ROC) curves were generated for the NLR, PLR, and MLR. Optimal cut-off values were determined as the points at which the Youden index (sensitivity + specificity - 1) was maximal. Based on the results of the ROC curve analysis, the patients were grouped into high MLR and low MLR groups. Recurrence rate, disease-free survival, and overall survival were compared between the two groups. The prognostic factors were investigated using univariate and multivariate Cox proportional hazards model. Results: The optimal cut-off value of MLR was 0.191 (AUC, 0.718; p < 0.001). Significantly more patients in the high MLR group experienced recurrence (60.3% vs. 15.6%, p < 0.0001) and cancer-related deaths (46.6% vs. 13.3%, p = 0.003). In multivariate analysis, advanced stage and high MLR were independent prognostic factors for disease-free survival and overall survival. Conclusion: Elevated MLR was significantly associated poor clinical outcomes in patients with non endometrioid endometrial cancer. Our findings suggest that MLR may be clinically reliable and useful as an independent prognostic marker for patients with non-endometrioid endometrial cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|