Pulmonary function responses in cats following long-term exposure to diesel exhaust
| Autor: | William J. Moorman, William E. Pepelko, John C. Clark, Joan K. Mattox |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Pathology medicine.medical_specialty Diesel exhaust Time Factors Vital Capacity Physiology Toxicology Pulmonary function testing Diffusing capacity medicine Animals Restrictive lung disease Lung volumes Respiratory system Lung Vehicle Emissions CATS Inhalation business.industry medicine.disease Petroleum Cats business Lung Volume Measurements Fuel Oils |
| Zdroj: | Journal of applied toxicology : JAT. 5(5) |
| ISSN: | 0260-437X |
| Popis: | Long-term inhalation studies were carried out to evaluate the toxic pulmonary effects of diesel engine emissions. Cats were exposed for over 2 years to whole, diluted diesel exhaust at levels expected to produce frank toxic effects. During the first 61 weeks of exposure, the cats received exhaust having a particulate level of 6 mg m-3. This was followed by a doubling of the exposure level from weeks 62 to 124 resulting in particulate levels of 12 mg m-3. No definitive pattern of pulmonary function response was observed following 61 weeks; however, a classic pattern of restrictive lung disease was found at 124 weeks. The significantly reduced lung volumes and diffusing capacity were indicative of a pulmonary interstitial response which was later verified by histopathology. |
| Databáze: | OpenAIRE |
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