DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families
| Autor: | Peter L. Pearson, Emma van der Meulen, Nicole Oteman, H Schelleman, Jan K. Buitelaar, Richard J. Sinke, Steven C. Bakker |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Linkage disequilibrium Nerve Tissue Proteins Minisatellite Repeats Linkage Disequilibrium Cellular and Molecular Neuroscience Gene Frequency Tandem repeat Cognitive neurosciences [UMCN 3.2] Polymorphism (computer science) mental disorders Determinants in Health and Disease [EBP 1] Humans Receptors Dopamine D5 Allele Allele frequency Alleles Genetics (clinical) Netherlands Dopamine transporter Family Health Genetics Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Polymorphism Genetic biology Receptors Dopamine D2 Receptors Dopamine D1 Receptors Dopamine D4 Haplotype Membrane Transport Proteins Psychiatry and Mental health Logistic Models Haplotypes Attention Deficit Disorder with Hyperactivity biology.protein Microsatellite Female Microsatellite Repeats |
| Zdroj: | American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 132B, 1, pp. 50-52 American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 132B, 50-52 |
| ISSN: | 1552-4841 |
| Popis: | Recent meta-analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention-deficit hyperactivity disorder (ADHD), although single studies frequently failed to show significant association. In a family-based sample of 236 Dutch children with ADHD, we have investigated the previously described variable number of tandem repeat (VNTR) polymorphisms and two additional microsatellites at the DAT1 and DRD4 loci. DRD5 was investigated using the microsatellite that was previously found to be associated. Transmission disequilibrium tests (TDTs) did not show preferential transmission of alleles or two-marker haplotypes to affected offspring. These data suggest that DAT1, DRD4, and DRD5 do not contribute substantially to ADHD in the Dutch population. |
| Databáze: | OpenAIRE |
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