Supraspinal interaction between HIV-1-gp120 and cannabinoid analgesic effectiveness
| Autor: | Josée Guindon, Jonathan Palma, Khalid Benamar, Madhusudhanan Narasimhan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Agonist Cannabinoid receptor medicine.drug_class Morpholines medicine.medical_treatment Analgesic Human immunodeficiency virus (HIV) Pain HIV Envelope Protein gp120 Naphthalenes Pharmacology medicine.disease_cause Periaqueductal gray Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine Animals Periaqueductal Gray Pain Measurement Cannabinoid Receptor Agonists Pain modulation Analgesics Cannabinoids business.industry General Medicine Endocannabinoid system Benzoxazines 030104 developmental biology lipids (amino acids peptides and proteins) Cannabinoid Analgesia business 030217 neurology & neurosurgery |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 391:1157-1161 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/s00210-018-1533-1 |
| Popis: | The growing therapeutic use (self-medication) of cannabinoids by HIV-1 infected people, and the recent interest in the possible medicinal use of cannabinoids, particularly in pain management, create an urgent need to identify their potential interactions with HIV-1. The goal here is to determine any interaction between proteins of HIV-1 and the analgesic effectiveness of cannabinoid at supraspinal level. Young adult male rats (Sprague-Dawley) were stereotaxically pretreated with HIV-1 envelope glycoprotein 120 (gp120) into the periaqueductal grey area (PAG), the primary control center of pain modulation. Then, we examined its effect on cannabinoid receptor agonist WIN55,212–2-induced analgesia. Our results demonstrated that gp120 in PAG diminished the analgesic effectiveness of this cannabinoid agonist. These results suggest that gp120 may interact with the cannabinoid system through the descending modulatory pain pathways centered in the PAG to impair the analgesic effectiveness of cannabinoids. |
| Databáze: | OpenAIRE |
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