N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation
| Autor: | Ivan Donati, Federica Vecchies, Pasquale Sacco, Michela Cok, Marco Viola, Franco Furlani, Eleonora Marsich |
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| Přispěvatelé: | Cok, M., Viola, M., Vecchies, F., Sacco, P., Furlani, F., Marsich, E., Donati, I. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hydrogel formation
Polymers and Plastics Biocompatibility N-isopropyl modified chitosan pH-stimulus Rheology Thermal stimulus macromolecular substances 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Chitosan chemistry.chemical_compound Thermal stimulation Materials Chemistry Solubility Thermo responsive chemistry.chemical_classification Organic Chemistry pH-stimulu technology industry and agriculture 021001 nanoscience & nanotechnology 0104 chemical sciences carbohydrates (lipids) chemistry Chemical engineering 0210 nano-technology Isopropyl |
| Popis: | The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments. |
| Databáze: | OpenAIRE |
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