Risk of diabetes after para-aortic radiation for testicular cancer

Autor: Peter De Brouwer, Ben G. L. Vanneste, Flora E. van Leeuwen, J. Martijn Kerst, Sjoukje Lubberts, Alphonsus C. M. van den Bergh, Tineke J. Smilde, J. Alfred Witjes, Jourik A. Gietema, Berthe M.P. Aleman, Maureen J.B. Aarts, O. W. M. Meijer, Maarten C.C.M. Hulshof, Gerard Groenewegen, Simon Horenblas, Ronald de Wit, Katarzina Jóźwiak, Michael Schaapveld, Luca Incrocci, Hetty A van den Berg, Harmke J. Groot, Alexandra W. van den Belt-Dusebout
Přispěvatelé: Radiotherapy, Medical Oncology, CCA - Cancer Treatment and Quality of Life, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie, Promovendi ODB, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), Radiation Oncology, Epidemiology and Data Science, APH - Quality of Care, CCA - Cancer Treatment and quality of life
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Cancer Research
Epidemiology
medicine.medical_treatment
Cohort Studies
MELLITUS
0302 clinical medicine
GERM-CELL CANCER
Cancer Survivors
education.field_of_study
030219 obstetrics & reproductive medicine
Incidence (epidemiology)
Incidence
LONG-TERM SURVIVORS
Type 2 diabetes
3. Good health
Treatment Outcome
Oncology
CARDIOVASCULAR-DISEASE
030220 oncology & carcinogenesis
Cohort study
RADIOTHERAPY
Adult
medicine.medical_specialty
Diabetes risk
Population
Article
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
Testicular cancer
Testicular Neoplasms
SDG 3 - Good Health and Well-being
Diabetes mellitus
Internal medicine
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
SURVEILLANCE
medicine
Diabetes Mellitus
Humans
education
CARBOPLATIN
business.industry
Dose-Response Relationship
Radiation
STAGE-I SEMINOMA
medicine.disease
Confidence interval
Radiation therapy
business
FOLLOW-UP
A-REPORT
Orchiectomy
Zdroj: Groot, H J, Gietema, J A, Aleman, B M P, Incrocci, L, de Wit, R, Witjes, J A, Groenewegen, G, de Brouwer, P, Meijer, O W M, Hulshof, M C C M, van den Berg, H A, Smilde, T J, Vanneste, B G L, Aarts, M J, van den Bergh, A C M, Kerst, J M, van den Belt-Dusebout, A W, Lubberts, S, Jóźwiak, K, Horenblas, S, van Leeuwen, F E & Schaapveld, M 2018, ' Risk of diabetes after para-aortic radiation for testicular cancer ', British Journal of Cancer, vol. 119, no. 7, pp. 901-907 . https://doi.org/10.1038/s41416-018-0248-x
British Journal of Cancer, 119(7), 901-907. Nature Publishing Group
British journal of cancer, 119(7), 901-907. Nature Publishing Group
British Journal of Cancer, 119, 901-907
British Journal of Cancer
British Journal of Cancer, 119, 7, pp. 901-907
ISSN: 0007-0920
DOI: 10.1038/s41416-018-0248-x
Popis: BACKGROUND: While the risk of diabetes is increased following radiation exposure to the pancreas among childhood cancer survivors, its association among testicular cancer (TC) survivors has not been investigated.METHODS: Diabetes risk was studied in 2998 1-year TC survivors treated before 50 years of age with orchidectomy with/without radiotherapy between 1976 and 2007. Diabetes incidence was compared with general population rates. Treatment-specific risk of diabetes was assessed using a case-cohort design.RESULTS: With a median follow-up of 13.4 years, 161 TC survivors were diagnosed with diabetes. Diabetes risk was not increased compared to general population rates (standardised incidence ratios (SIR): 0.9; 95% confidence interval (95% CI): 0.7-1.1). Adjusted for age, para-aortic radiotherapy was associated with a 1.66-fold (95% CI: 1.05-2.62) increased diabetes risk compared to no radiotherapy. The excess hazard increased with 0.31 with every 10 Gy increase in the prescribed radiation dose (95% CI: 0.11-0.51, P = 0.003, adjusted for age and BMI); restricted to irradiated patients the excess hazard increased with 0.33 (95% CI:-0.14 to 0.81, P = 0.169) with every 10 Gy increase in radiation dose.CONCLUSION: Compared to surgery only, para-aortic irradiation is associated with increased diabetes risk among TC survivors.
Databáze: OpenAIRE
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