Isoenzyme pattern of alkaline phosphatase in the serum of children with leukaemia after long-term chemotherapy
| Autor: | J. Ohlen, H. H. Völker, H. U. Schwenk |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Time Factors Adolescent medicine.medical_treatment Clinical Biochemistry Normal values Biology Biochemistry Gastroenterology Isoenzyme pattern Internal medicine medicine Humans Liver damage Child Chemotherapy Age Factors Infant Osteoblast General Medicine Alkaline Phosphatase Enzyme assay Leukemia Lymphoid Isoenzymes medicine.anatomical_structure Child Preschool Immunology biology.protein Lymphoblastic leukaemia Alkaline phosphatase Drug Therapy Combination |
| Zdroj: | European Journal of Clinical Investigation. 7:451-454 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1977.tb01633.x |
| Popis: | Chemotherapy was discontinued in thirteen children with acute lymphoblastic leukaemia after 2–3 years without relapse. In the following months, a continuous increase was observed in the serum alkaline phosphatase. A maximum was reached at different times but all patients had normal values again after 19 months. The rise in the total activity is due to an isolated increase of the bone isoenzyme. Increased enzyme activity in this post-therapy phase of the disease does not signify liver damage from the preceding chemotherapy, but rather is due to an increased osteoblast activity associated with a temporary increase in growth rate. |
| Databáze: | OpenAIRE |
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