Associations between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity
| Autor: | Grace Angélica de Oliveira Gomes, Ariene Angelini dos Santos-Orlandi, Carla Manuela Crispim Nascimento, Isabela Thaís Machado de Jesus, Fernando Augusto Vasilceac, Fabiana de Souza Orlandi, Henrique Pott-Junior, Márcia Regina Cominetti, Marisa Silvana Zazzetta, Letícia Pimenta Costa-Guarisco, Julio Cesar Ribeiro, Juliana Gomes Duarte |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Sarcopenia Aging medicine.medical_specialty Inflammation Type 2 diabetes Biochemistry Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Genetics medicine Humans Muscle Strength Obesity Molecular Biology Aged Hand Strength medicine.diagnostic_test business.industry Cell Biology Anthropometry medicine.disease Cross-Sectional Studies 030104 developmental biology Diabetes Mellitus Type 2 medicine.symptom business Lipid profile 030217 neurology & neurosurgery Dyslipidemia |
| Zdroj: | Experimental Gerontology. 151:111409 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2021.111409 |
| Popis: | Background We investigated the association between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity. Dynapenia is the age-related decline in muscle strength and results in negative outcomes to older adults. Accordingly, obesity is more prevalent throughout aging and is associated with comorbidities, such as type 2 diabetes, dyslipidemia and cardiovascular diseases. Both dynapenia and obesity are strongly linked to chronic inflammation, sharing common signaling pathways. Methods We recruited 247 older adults aged 60 or older and collected sociodemographic, anthropometric and metabolic data. Dynapenia was diagnosed according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Circulating inflammatory cytokines were measured in plasma using a multiplex panel kit. Anthropometric, sociodemographic, lipid profile, and fasting blood glucose were also assessed. Results Dynapenic participants were predominantly males (74.4%), had insufficiently active lifestyle and higher IL-10 plasma levels (0.95 pg/mL; 0.40–2.12). The prevalence of obesity was higher among non-dynapenic participants (45.3%; 95% CI, 37.7–53). In dynapenic older adults, obesity was predominant in males (53.6%) and subjects with normal muscle strength had higher serum levels of TNF-β (0.63 pg/mL; 0.30–1.30) and lower hand-grip strength (24 kg; 20.00–28.00). Using a multivariate quantile regression analysis, we found a strong and negative association between IL-10 and muscle strength. Conclusions This study can help to understand the association of inflammation, obesity and muscle strength to promote interventions in order to avoid or delay the negative outcomes associated with dynapenia and sarcopenia in older adults. |
| Databáze: | OpenAIRE |
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