Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
| Autor: | Sebastian Wagner, J. Philipp Benz, Elisabeth Windeisen-Holzhauser, Manfred Reppke, Christian Ludwig Maier, Kevin Schmitz |
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| Rok vydání: | 2019 |
| Předmět: |
Antifungal
Fungal Growth Fungal growth Antifungal Agents Research Facilities medicine.drug_class Science Libraries Ionic Liquids Microbial Sensitivity Tests Mycology Research and Analysis Methods Information Centers Microbiology Fungal Reproduction Microbial Control Microbial Physiology medicine Medicine and Health Sciences Fungal Spores Cellulose Pharmacology Antifungals Fungal attack Molecular Structure Antimicrobials Organic Compounds Archives Organic Chemistry Organisms Fungi Chemical Compounds Microbial Growth and Development Drugs Biology and Life Sciences Eukaryota Cultural heritage Chemistry Aspergillus Fungal Molds Physical Sciences Medicine Environmental science Biochemical engineering Research Article Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 9, p e0219650 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Early industrialization and the development of cheap production processes for paper have led to an exponential accumulation of paper-based documents during the last two centuries. Archives and libraries harbor vast amounts of ancient and modern documents and have to undertake extensive endeavors to protect them from abiotic and biotic deterioration. While services for mechanical preservation such as ex post de-acidification of historic documents are already commercially available, the possibilities for long-term protection of paper-based documents against fungal attack (apart from temperature and humidity control) are very limited. Novel processes for mechanical enhancement of damaged cellulosic documents use Ionic Liquids (IL) as essential process components. With some of these ILs having azole-functionalities similar to well-known fungicides such as Clotrimazole, the possibility of antifungal activities of these ILs was proposed but has not yet been experimentally confirmed.We evaluated the potency of four ILs with potential application in paper restoration for suppression of fungal growth on five relevant paper-infesting molds. The results revealed a general antifungal activity of all ILs, which increased with the size of the non-polar group. Physiological experiments and ultimate elemental analysis allowed to determine the minimal inhibitory concentration of each IL as well as the residual IL concentration in process-treated paper. These results provide valuable guidelines for IL-applications in paper restoration processes with antifungal activity as an added benefit. With azoles remaining in the paper after the process, simultaneous repair and biotic protection in treated documents could be facilitated. |
| Databáze: | OpenAIRE |
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