rHuEPO Hyporesponsiveness and Related High Dosages Are Associated with Hyperviscosity in Maintenance Hemodialysis Patients
| Autor: | Osman Ilhan, Selami Kocak Toprak, Emre Tutal, Siren Sezer, Hatice Saglam, Zeynep Bal, Meltem Bay, Mehtap Erkmen Uyar |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_treatment Blood viscosity Drug Resistance Myocardial Infarction lcsh:Medicine Hyperviscosity Drug resistance lcsh:Technology Gastroenterology Hemoglobins Prospective Studies lcsh:Science Prospective cohort study General Environmental Science Anemia Phosphorus General Medicine Middle Aged Blood Viscosity Recombinant Proteins Female Hemodialysis Research Article medicine.drug Adult medicine.medical_specialty Article Subject Side effect Iron General Biochemistry Genetics and Molecular Biology Arteriovenous Shunt Surgical Renal Dialysis Thromboembolism Internal medicine medicine Humans Erythropoietin Aged lcsh:T business.industry lcsh:R medicine.disease Endocrinology Kidney Failure Chronic Calcium lcsh:Q business |
| Zdroj: | The Scientific World Journal, Vol 2013 (2013) The Scientific World Journal |
| ISSN: | 1537-744X |
| DOI: | 10.1155/2013/792698 |
| Popis: | Objective. Increased viscosity may increase the risk of thrombosis or thromboembolic events. Recombinant human erythropoietin (rHuEPO) is the key stone treatment in anemic ESRD patients with the thrombotic limiting side effect. We evaluated the influence of clinical and laboratory findings on plasma viscosity in MHD patients in the present study. Method. After applying exclusion criteria 84 eligible MHD patients were included (30 female, age: years). Results. Patients with high viscosity had longer MHD history, calcium × phosphorus product, and higher rHuEPO requirement (356.4 versus 204.2 U/kg/week, : 0.006). rHuEPO hyporesponsiveness was also more common in hyperviscosity group. According to HD duration, no rHuEPO group had the longest and the low rHuEPO dosage group had the shortest duration. Despite similar Hb levels, 68% of patients in high rHuEPO dosage group; and 38.7% of patients in low rHuEPO dosage group had higher plasma viscosity ( : 0.001). Patients with hyperviscosity had higher rHuEPO/Hb levels ( : 0.021). Binary logistic regression analyses revealed that rHuEPO hyporesponsiveness was the major determinant of hyperviscosity. Conclusion. We suggest that the hyperviscous state of the hemodialysis patients may arise from the inflammatory situation of long term HD, the calcium-phosphorus mineral abnormalities, rHuEPO hyporesponsiveness, and related high dosage requirements. |
| Databáze: | OpenAIRE |
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