Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes

Autor: Iguatemy Lourenço Brunetti, V.B.B. Folgado, Maria Tereza Pepato, Isis do Carmo Kettelhut
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP)
Rok vydání: 2001
Předmět:
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 3, Pages: 389-395, Published: MAR 2001
Brazilian Journal of Medical and Biological Research, Vol 34, Iss 3, Pp 389-395 (2001)
Brazilian Journal of Medical and Biological Research v.34 n.3 2001
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Scopus-Elsevier
SciELO
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0100-879X
DOI: 10.1590/s0100-879x2001000300014
Popis: Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:52:38Z No. of bitstreams: 1 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) Made available in DSpace on 2013-08-22T18:52:38Z (GMT). No. of bitstreams: 1 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) Previous issue date: 2001-03-01 Made available in DSpace on 2013-09-30T18:07:38Z (GMT). No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Previous issue date: 2001-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:23:45Z No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Made available in DSpace on 2014-05-20T13:23:45Z (GMT). No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Previous issue date: 2001-03-01 Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity. Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Bioquímica Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas
Databáze: OpenAIRE