Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
Autor: | Iguatemy Lourenço Brunetti, V.B.B. Folgado, Maria Tereza Pepato, Isis do Carmo Kettelhut |
---|---|
Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
Rok vydání: | 2001 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty Physiology Urinary system Immunology Drug Evaluation Preclinical Biophysics Adipose tissue Decoction Body weight Biochemistry Streptozocin Diabetes Mellitus Experimental antidiabetic plant Fluid intake chemistry.chemical_compound Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Rats Wistar General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Analysis of Variance lcsh:R5-920 Plants Medicinal Streptozotocin Diabetes Traditional medicine Plant Extracts business.industry General Neuroscience Body Weight Cell Biology General Medicine medicine.disease Rats Plant Leaves Endocrinology lcsh:Biology (General) chemistry Urea Eugenia jambolana hyperglycemia diabetic rats lcsh:Medicine (General) business |
Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 3, Pages: 389-395, Published: MAR 2001 Brazilian Journal of Medical and Biological Research, Vol 34, Iss 3, Pp 389-395 (2001) Brazilian Journal of Medical and Biological Research v.34 n.3 2001 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Scopus-Elsevier SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
ISSN: | 0100-879X |
DOI: | 10.1590/s0100-879x2001000300014 |
Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:52:38Z No. of bitstreams: 1 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) Made available in DSpace on 2013-08-22T18:52:38Z (GMT). No. of bitstreams: 1 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) Previous issue date: 2001-03-01 Made available in DSpace on 2013-09-30T18:07:38Z (GMT). No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Previous issue date: 2001-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:23:45Z No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Made available in DSpace on 2014-05-20T13:23:45Z (GMT). No. of bitstreams: 2 S0100-879X2001000300014.pdf: 148636 bytes, checksum: ca3c1d01f0714ac03e2b0fc6edeff1f6 (MD5) S0100-879X2001000300014.pdf.txt: 26852 bytes, checksum: 4c4f2c92ba8614e99ffbdfa5732a2194 (MD5) Previous issue date: 2001-03-01 Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no antidiabetic activity. Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Bioquímica Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas |
Databáze: | OpenAIRE |
Externí odkaz: |