Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics
| Autor: | Panu Hakola, Olli-Pekka Ryynänen, Jari Karhu, Kim A. Bergström, Jaana Föhr, Jari Tiihonen, Kuikka Jt |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Striatal dopamine medicine.medical_specialty Nerve Tissue Proteins Striatum Violence Basal Ganglia General Biochemistry Genetics and Molecular Biology Iodine Radioisotopes Limbic system Cocaine Dopamine receptor D2 Internal medicine Humans Medicine Single-Blind Method Psychiatry Alleles Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins Substance dependence Receptors Dopamine D2 business.industry Mental Disorders Dopaminergic Membrane Transport Proteins General Medicine Middle Aged medicine.disease Corpus Striatum DA Transporter Alcoholism Endocrinology medicine.anatomical_structure Female Crime Animal studies Carrier Proteins business |
| Zdroj: | Nature Medicine. 1:654-657 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/nm0795-654 |
| Popis: | Animal studies suggest that development of substance dependence is associated with dopaminergic activity in striatum and the limbic system. Several genetic studies indicate that allele A1 is associated with both D2 receptor density and alcoholism, although these findings have remained controversial. We studied striatal dopamine (DA) re-uptake site densities in 48 subjects (19 healthy controls, 19 habitually impulsive violent alcoholics, and 10 non-violent alcoholics) with single photon emission computed tomography (SPECT) using iodine-123-labelled 2 beta-carbomethoxy-3 beta(4-iodophenyl)tropane, (beta-CIT) as a tracer. Blind quantitative analysis revealed that the striatal DA transporter density was markedly lower in non-violent alcoholics than in healthy controls (P0.001), while violent alcoholics had slightly higher DA transporter densities than controls (P0.10). The results indicate that both types of alcoholics have alterations in striatal dopaminergic system, though these occur in opposite directions. |
| Databáze: | OpenAIRE |
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