Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A Potential Therapeutic Target in Alzheimer’s Disease
| Autor: | Vincenza Spera, Tatiana Sitnikova, Samuel Gazecki, Eric Bui, Paolo Cassano, Maria Angela Franceschini, Luis De Taboada, Marco Maiello, Meredith J. Ward, Parya Farzam, Michael R. Hamblin, Jeremy W. Hughes |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Dose dependence Pilot Projects Neuropsychological Tests Electroencephalography 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine medicine Humans Premovement neuronal activity Single-Blind Method 0501 psychology and cognitive sciences Gamma power medicine.diagnostic_test Pulse (signal processing) business.industry Spectrum Analysis General Neuroscience 05 social sciences Brain General Medicine Healthy Volunteers Eeg oscillations Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Cerebral blood flow Cerebrovascular Circulation Scalp Cardiology Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 83:1481-1498 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Transcranial photobiomodulation (tPBM) has recently emerged as a potential cognitive enhancement technique and clinical treatment for various neuropsychiatric and neurodegenerative disorders by delivering invisible near-infrared light to the scalp and increasing energy metabolism in the brain. Objective: We assessed whether transcranial photobiomodulation with near-infrared light modulates cerebral electrical activity through electroencephalogram (EEG) and cerebral blood flow (CBF). Methods: We conducted a single-blind, sham-controlled pilot study to test the effect of continuous (c-tPBM), pulse (p-tPBM), and sham (s-tPBM) transcranial photobiomodulation on EEG oscillations and CBF using diffuse correlation spectroscopy (DCS) in a sample of ten healthy subjects [6F/4 M; mean age 28.6±12.9 years]. c-tPBM near-infrared radiation (NIR) (830 nm; 54.8 mW/cm2; 65.8 J/cm2; 2.3 kJ) and p-tPBM (830 nm; 10 Hz; 54.8 mW/cm2; 33%; 21.7 J/cm2; 0.8 kJ) were delivered concurrently to the frontal areas by four LED clusters. EEG and DCS recordings were performed weekly before, during, and after each tPBM session. Results: c-tPBM significantly boosted gamma (t = 3.02, df = 7, p |
| Databáze: | OpenAIRE |
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