Longitudinal Study of Intestinal Symptoms and Fecal Continence in Patients With Conformal Radiotherapy for Prostate Cancer
| Autor: | Simone Kerndl, Reinhard Thamm, Sabrina T. Astner, Frank B. Zimmermann, Christine Heinrich, Monika Keller, Michael Molls, N. Prause, Hans Geinitz, Raymonde Busch, Christian Pehl, C. Scholz |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Cancer Research Longitudinal study medicine.medical_specialty medicine.medical_treatment Gastroenterology Prostate cancer Prostate Surveys and Questionnaires Internal medicine Prevalence medicine Humans Fecal incontinence Radiology Nuclear Medicine and imaging Large intestine Prospective Studies Defecation Feces Aged Aged 80 and over Radiation business.industry Rectum Prostatic Neoplasms Cancer Middle Aged Prostate-Specific Antigen medicine.disease Surgery Radiation therapy Mucus medicine.anatomical_structure Oncology Regression Analysis Radiotherapy Conformal medicine.symptom Gastrointestinal Hemorrhage business Fecal Incontinence |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 79:1373-1380 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2010.01.033 |
| Popis: | Purpose To prospectively assess the intestinal symptoms and fecal continence in patients who had undergone conformal radiotherapy (CRT) for prostate cancer. Methods and Materials A total of 78 men who had undergone definitive CRT for prostate cancer were evaluated. The patients were assessed before, during (treatment Weeks 4 and 6), and 2, 12, and 24 months after CRT completion. The intestinal symptoms and fecal continence were evaluated with comprehensive standardized questionnaires. Results The intestinal symptoms were mostly intermittent, with only a small minority of patients affected daily. Defecation pain, fecal urge, and rectal mucous discharge increased significantly during therapy. Defecation pain and rectal mucous discharge had returned to baseline levels within 8 weeks and 1 year after CRT, respectively. However, fecal urge remained significantly elevated for ≤1 year and then returned toward the pretreatment values. The prevalence of rectal bleeding was significantly elevated 2 years after CRT. Fecal continence deteriorated during CRT and remained impaired at 1 year after treatment. Incontinence was mostly minor, occurring less than once per week and predominantly affecting incontinence for gas. Conclusion Intestinal symptoms and fecal incontinence increased during prostate CRT. Except for rectal bleeding, the intestinal symptoms, including fecal incontinence, returned to baseline levels within 1–2 years after CRT. Thus, the rate of long-term late radiation-related intestinal toxicity was low. |
| Databáze: | OpenAIRE |
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