Gender, Race, and Age at Diagnosis as Risk Factors for Metastasis or Recurrence among 1,657 Thyroid Cancer Patients Treated with Radioiodine across 40 Years in Singapore

Autor:	Anthony S. W. Goh, Winnie Wing Chuen Lam, David Chee Eng Ng, Hui K Gan, Wai Yin Wong, Yung Hsiang Kao, Sumbul Zaheer, Kelvin Siu Hoong Loke
Rok vydání:	2015
Předmět:	Adult Male Cancer Research medicine.medical_specialty Adolescent Metastasis Young Adult Race (biology) Age Distribution Risk Factors Internal medicine Prevalence Carcinoma Humans Medicine Thyroid Neoplasms Sex Distribution Young adult Child Survival rate Thyroid cancer Aged Retrospective Studies Aged 80 and over Gynecology Singapore business.industry Racial Groups Retrospective cohort study Hematology Odds ratio Middle Aged medicine.disease Survival Rate Treatment Outcome Oncology Female Neoplasm Recurrence Local business
Zdroj:	Oncology Research and Treatment. 38:679-682
ISSN:	2296-5262 2296-5270
DOI:	10.1159/000442114
Popis:	Background: To obtain descriptive data on Singaporean thyroid cancer patients treated with radioiodine and to assess gender, race, and age at diagnosis as risk factors for metastasis or recurrence. Methods: This is a retrospective study of all thyroid cancer patients treated with radioiodine of any prescribed activity at our institution. Data collected included: age at diagnosis, gender, race, histopathological type, duration of follow-up, and metastasis at diagnosis (locoregional or distant) or recurrence at any time. Gender, race, and age at diagnosis were analyzed for possible associations with metastasis or recurrence. Results: A total of 1,657 thyroid cancer patients were treated with radioiodine across a 40-year period; mean follow-up 6.4 ± 6.9 years (median 4.2 years). 656 (39.6%) patients had metastasis or recurrence over the duration of their follow-up. Male gender (odds ratio (OR) 1.38; p = 0.006), Malay race (OR 1.71; p < 0.0001), and age at diagnosis of > 46 years (OR 1.31; p = 0.007) were significantly associated with metastasis or recurrence. Conclusion: Male gender, Malay race, and age at diagnosis of > 46 years were significant risk factors for metastasis or recurrence in Singaporean thyroid cancer patients treated with radioiodine.
Databáze:	OpenAIRE
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