Enhanced effects of central angiotensin II on cardiovascular and drinking responses in inbred polydipsic (STR/N) mice
| Autor: | Takato Kunitake, Hiroshi Kannan, Chun-Ping Chu, Shoichi Watanabe, Kazuo Kato, Youichi Ueta, De-Lai Qiu |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Urinary system Drinking Behavior Hemodynamics Blood Pressure Cerebral Ventricles Excretion Mice Polyuria Inbred strain Heart Rate Internal medicine Animals Medicine Molecular Biology Injections Intraventricular Mice Inbred ICR business.industry Angiotensin II General Neuroscience Sodium Mice Mutant Strains eye diseases Diuresis Blood pressure Endocrinology Potassium Neurology (clinical) medicine.symptom business Polydipsia Developmental Biology |
| Zdroj: | Brain Research. 962:129-134 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(02)03981-1 |
| Popis: | STR/N, an inbred strain of mice, is known to exhibit extreme polydipsia and polyuria. The objective of this study was to investigate the possible reasons for polydipsia. First, comparisons were made between STR/N mice and control mice from the Institute of Cancer Research (ICR) concerning daily drinking, urinary excretion, and basal cardiovascular function. Then, since angiotensin II (ANG II) is a potent stimulus for drinking behavior, we investigated the effects of intracerebroventricular (i.c.v.) administration of ANG II on cardiovascular and water intake responses. Daily water intake, food intake, urinary volume, and urinary electrolytes (Na and K) excretion were larger in STR/N mice than in ICR mice, and the basal blood pressure was significantly lower in STR/N mice than in ICR mice. The i.c.v. administration of ANG II (10 pmol/per mouse) resulted in increased mean arterial blood pressure (MAP) and water intake in both STR/N and ICR mice, but the changes in MAP were significantly larger in STR/N mice than in ICR mice. These results suggest that polydipsia in STR/N mice is at least partially attributable to high sensitivity of central ANG II receptors and low MAP. |
| Databáze: | OpenAIRE |
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