Volumetric and anatomical MRI for hypoxic–ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments
| Autor: | Jon E. Tyson, Nehal A. Parikh, Robert E. Lasky, Christen N. Garza, Eliana E Bonfante-Mejia, Seetha Shankaran |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Encephalopathy Gestational Age Bayley Scales of Infant Development Article Hypoxic Ischemic Encephalopathy law.invention White matter 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Hypothermia Induced law 030225 pediatrics medicine Humans outcome assessment Psychomotor learning cerebral palsy medicine.diagnostic_test business.industry Infant Newborn Obstetrics and Gynecology Magnetic resonance imaging Organ Size Hypothermia medicine.disease Magnetic Resonance Imaging 3. Good health medicine.anatomical_structure hypoxia-ischemia brain Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/jp.2008.184 |
| Popis: | To relate volumetric magnetic resonance imaging (MRI) findings to hypothermia therapy and neurosensory impairments. Newborns ⩾36 weeks’ gestation with hypoxic–ischemic encephalopathy who participated in the National Institute of Child Health and Human Development hypothermia randomized trial at our center were eligible. We determined the relationship between hypothermia treatment and usual care (control) to absolute and relative cerebral tissue volumes. Furthermore, we correlated brain volumes with death or neurosensory impairments at 18 to 22 months. Both treatment groups were comparable before randomization. Total brain tissue volumes did not differ in relation to treatment assignment. However, relative volumes of subcortical white matter were significantly larger in hypothermia-treated than control infants. Furthermore, relative total brain volumes correlated significantly with death or neurosensory impairments. Relative volumes of the cortical gray and subcortical white matter also correlated significantly with Bayley Scales psychomotor development index. Selected volumetric MRI findings correlated with hypothermia therapy and neurosensory impairments. Larger studies using MRI brain volumes as a secondary outcome measure are needed. |
| Databáze: | OpenAIRE |
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