Phase II trial of ifosfamide and mesna in patients with advanced or recurrent squamous carcinoma of the cervix who had never received chemotherapy: A Gynecologic Oncology Group study
| Autor: | William P. McGuire, Thomas J. Patton, Katherine Y. Look, Gregory P. Sutton, John A. Blessing |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Urology Uterine Cervical Neoplasms Gynecologic oncology Carcinoma medicine Humans Ifosfamide Cervix Aged Mesna Aged 80 and over Chemotherapy business.industry Obstetrics and Gynecology Middle Aged medicine.disease Squamous carcinoma Surgery Radiation therapy medicine.anatomical_structure Carcinoma Squamous Cell Female business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 168:805-807 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/s0002-9378(12)90824-8 |
| Popis: | OBJECTIVE: Our objective was to determine the activity of ifosfamide and mesna in women with advanced or recurrent squamous carcinoma of the cervix who had never received chemotherapy. STUDY DESIGN: This is a phase II drug study in which the starting dose of ifosfamide was 1.5 gm/m 2 daily intravenously for 5 days. The starting dose of ifosfamide was reduced to 1.2 gm/m 2 daily in patients who had received prior radiotherapy. The uroprotector mesna was given intravenously with, and at 4 and 8 hours after, the administration of ifosfamide. Each dose of mesna was 20% of the total daily dose of ifosfamide. RESULTS: Fifty-six patients were placed in the study; 52 were evaluable for toxicity and 51 for response. Twenty-eight (54.9%) patients had previously undergone surgery and 46 (90.2%) had received radiotherapy before this trial. Gynecologic Oncology Group grade 3 or 4 granulocytopenia occurred in 7 (13.5%) patients, and 2 (3.9%) had grade 3 thrombocytopenia. Six (11.5%) patients had grade 3 or 4 neurotoxicity. Complete response was observed in 2 (3.9%) patients and partial responses in 6 (11.5%) patients, for a total response rate of 15.7% (95% confidence interval 7.02% to 28.59%). CONCLUSIONS: This response rate is higher than that reported by the Gynecologic Oncology Group in patients with previously treated squamous carcinoma of the cervix. Our findings fail to confirm that ifosfamide is a highly active agent in patients with squamous carcinoma of the cervix as reported by others; nonetheless, the observed activity of this drug deserves further study in combination therapy of squamous carcinoma of the cervix. |
| Databáze: | OpenAIRE |
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