Effect of partial and total cardiopulmonary bypass with whole blood or hemodilution priming on pulmonary surfactant activity
| Autor: | Richard T. Cathcart, Prakashchandra Joshi, Louis Pierucci, William Fraimow, Kouichi Tokunaga, David M. Kelsey, Allen L. Davies, Rudolph C. Camishion |
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| Rok vydání: | 1968 |
| Předmět: |
Extracorporeal Circulation
medicine.medical_specialty Time Factors medicine.medical_treatment Bronchial Arteries law.invention Dogs Pulmonary surfactant law medicine Cardiopulmonary bypass Animals Surface Tension Thoracotomy Lung Whole blood Heparin business.industry Extracorporeal circulation Thoracic Surgery Thorax medicine.anatomical_structure Regional Blood Flow Cardiothoracic surgery Anesthesia Surgery business Perfusion |
| Zdroj: | Journal of Surgical Research. 8:1-6 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(68)90124-8 |
| Popis: | 1. 1. Minimal surface tension of the lungs of dogs was estimated in terms of surfactant activity before, during, and after cardiopulmonary bypass. 2. 2. Surfactant values of normal lungs sampled before the operation ranged from 1.8–11.8 dynes per cm. 2 , averaging 5.1 dynes per cm. 2 3. 3. Animals perfused one or two hours with 50% hemodilution showed little change in surfactant values immediately after the perfusion was completed. However, in those that survived more than fifteen hours the values rose an average of 11.1 dynes per cm. 2 4. 4. 60% of animals perfused with whole blood for one hour had rises in surface tension (average 8.5 dynes/cm. 2 ) both at the completion of bypass and at the time of death. None of these dogs survived more than eight hours. 5. 5. No rise in minimal surface tension was observed in animals placed on controlled ventilation without cardiopulmonary by pass; only one of 6 animals with thoracotomy and heparin showed a persistent rise. 6. 6. Possible explanations for the temporary protection to lung surface afforded by hemodilution as compared to whole blood perfusion are discussed. |
| Databáze: | OpenAIRE |
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