Long-Term Results of Intensity-Modulated Radiotherapy for T4 Nasopharyngeal Carcinoma: New Insight into the Value of Concurrent Chemotherapy
Autor: | Ruiping Zhai, Juan Huang, Hongmei Ying, Chaosu Hu, Fangfang Kong |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Young Adult 03 medical and health sciences 0302 clinical medicine Concurrent chemotherapy Internal medicine medicine Humans Child Aged Chemotherapy Nasopharyngeal Carcinoma business.industry Significant difference Induction chemotherapy Chemoradiotherapy General Medicine Long term results Middle Aged medicine.disease Radiation therapy 030104 developmental biology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Female Radiotherapy Intensity-Modulated Intensity modulated radiotherapy business |
Zdroj: | Cancer Investigation. 39:645-652 |
ISSN: | 1532-4192 0735-7907 |
Popis: | The aim of the study was to report long-term results of intensity-modulated radiotherapy for patients with T4 classification nasopharyngeal carcinoma (NPC). From September 2007 to January 2013, 155 patients were retrospectively analyzed. The estimated 10-year local recurrent-free survival (LRFS), regional recurrent-free survival (RRFS), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 79.4%, 93.2%, 69.0%, and 54.2%, respectively. Cycle number of chemotherapy was a significant predictor of LRFS, OS, and progression-free survival. There was no significant difference in survival rates between patients treated with induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) and patients with IC plus IMRT and adjuvant chemotherapy (AC). |
Databáze: | OpenAIRE |
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