Autoimmune polyglandular syndrome of adults: current ideas about predictors development of damage of a myocardium and diagnostics of components of a disease
| Autor: | Natalia V. Molashenko, Ekaterina A. Troshina, Elena N. Golovenko, Taras S. Panevin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty autoimmune polyglandular syndrome type 3 Myocarditis Graves' disease 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine medicine Adrenal insufficiency Endocrine system Autoimmune disease business.industry autoimmune polyglandular syndromes of adults Autoantibody General Medicine RC648-665 medicine.disease graves disease Endocrine pathology myocarditis antibodies to a myocardium adrenal insufficiency business Hormone |
| Zdroj: | Клиническая и экспериментальная тиреоидология, Vol 14, Iss 2, Pp 92-99 (2018) |
| ISSN: | 2310-3787 1995-5472 |
| DOI: | 10.14341/ket9641 |
| Popis: | The autoimmune polyglandular syndrome of adults (APS) is characterized by the damage of two and more endocrine glands leading more often to development of their hormonal insufficiency. The basis of most autoimmune endocrine diseases is lymphoid and macrophage infiltration of the target organ. Often in patients with one autoimmune disease, other components of the APS appear after a some time of latent period. Besides defeat organs of endocrine system which are including to the APS also not endocrine organs can be part of autoimmune defeat. Although defeat of cardiovascular system is not included in the structure of the APS, in some clinical cases development of damage of a myocardium in the absence of clinically shown damage of heart against the background of the combined autoimmune endocrine pathology is described. The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state. The most promising diagnostic methods for this condition are the determination of autoantibodies to myocardial components and magnetic resonance imaging of the heart. In clinical practice, it is possible to widely use the definition of antibodies to myocardium by indirect immunofluorescence, as well as using standardized immunoenzyme test systems.The saved-up clinical this development of damage of a myocardium on the background of autoimmune endocrine insufficiency and also laboratory and instrumental methods of diagnostics is presented in the review at this state. |
| Databáze: | OpenAIRE |
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