The Backbone N-(4-Azidobutyl) Linker for the Preparation of Peptide Chimera
| Autor: | Jaume Adan, Ana I. Fernández-Llamazares, Francesc Mitjans, Jesús García, David Meunier, Fernando Albericio, Jan Spengler |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Azides Molecular Structure Acylation Organic Chemistry Cilengitide Peptide Alkylation Peptides Cyclic Biochemistry Combinatorial chemistry chemistry.chemical_compound chemistry Click chemistry Animals Molecule Click Chemistry Azide Physical and Theoretical Chemistry Linker Snake Venoms |
| Zdroj: | Organic Letters. 15:4572-4575 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol402150m |
| Popis: | A robust synthetic strategy for the introduction of the N-(4-azidobutyl) linker into peptides using standard SPPS techniques is described. Based on the example of Cilengitide it is shown that the N-(4-azidobutyl) group exerts similar conformational restraints as a backbone N-Me group and allows conjugation of a desired molecule either via click chemistry or-after azide reduction-via acylation or reductive alkylation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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