Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex

Autor:	Ankita Shukla, Mohammad Afsar, Taran Khanam, Nelam Kumar, Faiz Ali, Sanjay Kumar, Farheen Jahan, Ravishankar Ramachandran
Rok vydání:	2022
Předmět:	Ligases X-Ray Diffraction DNA Repair Structural Biology Scattering Small Angle DNA-(Apurinic or Apyrimidinic Site) Lyase Humans Tuberculosis General Medicine DNA Mycobacterium tuberculosis Molecular Biology Biochemistry
Zdroj:	International journal of biological macromolecules. 225
ISSN:	1879-0003
Popis:	The Class-II AP-endonuclease (XthA) is a mycobacterial DNA base excision repair (BER) pathway enzyme that functions in the initial steps. It acts on DNA substrates that contain abasic sites to create nicks with 3'-hydroxyl (OH) and 5'-deoxyribose phosphate (5'-dRP) moieties. The NAD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cf1df8c3986cbfdf26e2dd0b219f9b https://pubmed.ncbi.nlm.nih.gov/36395952 Zobrazit plný text záznamu Full Text from ScienceDirect