Whole-body MRI versus an [F-18]FDG-PET/CT-based reference standard for early response assessment and restaging of paediatric Hodgkin's lymphoma

Autor: Bart de Keizer, Federico Verzegnassi, Suzanne Spijkers, Goya Enríquez, Claudio Granata, Auke Beishuizen, Marrie C.A. Bruin, Thomas C. Kwee, Constantino Sábado, Elka Miller, Rutger A.J. Nievelstein, Annemieke S. Littooij, Nelleke Tolboom, Charlotte de Lange
Přispěvatelé: Guided Treatment in Optimal Selected Cancer Patients (GUTS), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Institut Català de la Salut, [Spijkers S] Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht/Wilhelmina Children’s Hospital, Utrecht University, Utrecht, The Netherlands. [Littooij AS, Tolboom N] Department of Radiology and Nuclear Medicine, University Medical Centre Utrecht/Wilhelmina Children’s Hospital, Utrecht, The Netherlands. Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands. [Kwee TC] Department of Radiology, Medical Imaging Centre, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. [Beishuizen A] Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands. Department of Paediatric Oncology/Haematology, Erasmus Medical Centre-Sophia Children’s Hospital, Rotterdam, The Netherlands. [Bruin MCA] Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands. [Enríquez G] Servei de Radiologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Sábado C] Servei d’Oncologia i Hematologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Pediatrics
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Hodgkin disease
Diffusion magnetic resonance imaging
PET/CT
Concordance
Whole body imaging
THERAPY
DISEASE
Cohen's kappa
Medicine
Radiology
Nuclear Medicine and imaging
Hodgkin
Malaltia de - Imatgeria
Child
MASSES
Other subheadings::Other subheadings::/diagnostic imaging [Other subheadings]
Neuroradiology
Whole-body imaging
Pediatria
medicine.diagnostic_test
business.industry
Positron emission tomography computed tomography
Otros calificadores::Otros calificadores::/diagnóstico por imagen [Otros calificadores]
Interventional radiology
General Medicine
Hodgkin's lymphoma
medicine.disease
observer variation
neoplasias::neoplasias por tipo histológico::linfoma::enfermedad de Hodgkin [ENFERMEDADES]
Lymphoma
Response assessment
Imatgeria per ressonància magnètica
Radiology
business
Neoplasms::Neoplasms by Histologic Type::Lymphoma::Hodgkin Disease [DISEASES]
Zdroj: European Radiology, 31(12), 8925-8936. SPRINGER
Scientia
European Radiology, 31(12), 8925-8936. Springer-Verlag
ISSN: 0938-7994
Popis: Objectives To compare WB-MRI with an [18F]FDG-PET/CT-based reference for early response assessment and restaging in children with Hodgkin’s lymphoma (HL). Methods Fifty-one children (ages 10–17) with HL were included in this prospective, multicentre study. All participants underwent WB-MRI and [18F]FDG-PET/CT at early response assessment. Thirteen of the 51 patients also underwent both WB-MRI and [18F]FDG-PET/CT at restaging. Two radiologists independently evaluated all WB-MR images in two separate readings: without and with DWI. The [18F]FDG-PET/CT examinations were evaluated by a nuclear medicine physician. An expert panel assessed all discrepancies between WB-MRI and [18F]FDG-PET/CT to derive the [18F]FDG-PET/CT-based reference standard. Inter-observer agreement for WB-MRI was calculated using kappa statistics. Concordance, PPV, NPV, sensitivity and specificity for a correct assessment of the response between WB-MRI and the reference standard were calculated for both nodal and extra-nodal disease presence and total response evaluation. Results Inter-observer agreement of WB-MRI including DWI between both readers was moderate (κ 0.46–0.60). For early response assessment, WB-MRI DWI agreed with the reference standard in 33/51 patients (65%, 95% CI 51–77%) versus 15/51 (29%, 95% CI 19–43%) for WB-MRI without DWI. For restaging, WB-MRI including DWI agreed with the reference standard in 9/13 patients (69%, 95% CI 42–87%) versus 5/13 patients (38%, 95% CI 18–64%) for WB-MRI without DWI. Conclusions The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric HL improved agreement with the [18F]FDG-PET/CT-based reference standard. However, WB-MRI remained discordant in 30% of the patients compared to standard imaging for assessing residual disease presence. Key Points • Inter-observer agreement of WB-MRI including DWI between both readers was moderate for (early) response assessment of paediatric Hodgkin’s lymphoma. • The addition of DWI to the WB-MRI protocol in early response assessment and restaging of paediatric Hodgkin’s lymphoma improved agreement with the [18F]FDG-PET/CT-based reference standard. • WB-MRI including DWI agreed with the reference standard in respectively 65% and 69% of the patients for early response assessment and restaging.
Databáze: OpenAIRE
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