Allergen Sensitization and Asthma Outcomes among World Trade Center Rescue and Recovery Workers
| Autor: | Erin A. West, Juan P. Wisnivesky, Paula J. Busse, Laura Crowley, Denise Harrison, Steven B. Markowitz, Alex D. Federman, Belen Rojano, Emily Ferdermann |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Health Toxicology and Mutagenesis lcsh:Medicine Cockroaches Immunoglobulin E indoor allergens sensitization immunoglobulin E Cohort Studies Allergic sensitization WTC-related asthma 0302 clinical medicine Risk Factors immune system diseases Prevalence Rescue Work asthma morbidity Prospective Studies 030212 general & internal medicine Prospective cohort study Sensitization education.field_of_study biology Pyroglyphidae asthma outcomes 3. Good health medicine.anatomical_structure Asthma Control Questionnaire Health Resources Female mini asthma quality of life questionnaire medicine.medical_specialty Population complex mixtures Article 03 medical and health sciences asthma quality of life Internal medicine medicine Animals Humans Risk factor education Asthma business.industry lcsh:R Public Health Environmental and Occupational Health Environmental Exposure Allergens medicine.disease World Trade Center respiratory tract diseases asthma control 030228 respiratory system Quality of Life biology.protein allergen exposure Morbidity September 11 Terrorist Attacks business |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 5 International Journal of Environmental Research and Public Health, Vol 16, Iss 5, p 737 (2019) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph16050737 |
| Popis: | A large number of World Trade Center (WTC) rescue and recovery workers are affected by asthma. While physical and mental health comorbidities have been associated with poor asthma control in this population, the potential role of allergen sensitization is unknown. This study examined the association of indoor sensitization and exposure as a risk factor for increased asthma morbidity in WTC workers. We used data from a prospective cohort of 331 WTC workers with asthma. Sensitization to indoor allergens was assessed by measurement of antigen-specific serum immunoglobulin E (IgE) levels. We used validated tools to evaluate the exposure to indoor allergens. Asthma morbidity outcomes included level of control (Asthma Control Questionnaire, ACQ), quality of life (Asthma Quality of Life Questionnaire, AQLQ) and acute resource utilization. The prevalence of sensitization to cat, dog, mouse, dust mite, cockroach, and mold allergens were 33%, 21%, 17%, 40%, 17%, and 17%, respectively. Unadjusted and regression analyses showed no significant relationship between sensitization and increased asthma morbidity (p > 0.05 for all comparisons), except for sensitization to Aspergillus Fumigatus, cat and mouse epithelium, which were associated with decreased morbidity. |
| Databáze: | OpenAIRE |
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