Childhood narcolepsy with cataplexy: comparison between post-H1N1 vaccination and sporadic cases
| Autor: | Hanna Peltola, Fabio Pizza, Markku Partinen, Giuseppe Plazzi, Tomi Sarkanen, Keivan Kaveh Moghadam |
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| Přispěvatelé: | F. Pizza, H. Peltola, T. Sarkanen, K. K. Moghadam, G. Plazzi, M. Partinen |
| Rok vydání: | 2013 |
| Předmět: |
adverse effects/immunology
Male medicine.medical_specialty Pediatrics Cataplexy Polysomnography chemically induced/physiopathology Video Recording immunology Influenza A Virus H1N1 Subtype Narcolepsy with cataplexy adverse effects/immunology Male Narcolepsy Influenza A Virus medicine Humans H1N1 Subtype Child chemically induced/physiopathology Polysomnography Video Recording Narcolepsy immunology Influenza Vaccine medicine.diagnostic_test business.industry Female Influenza Vaccines General Medicine Anthropometry medicine.disease H1n1 pandemic Vaccination Child Female Humans Influenza A Viru Nocturnal sleep Physical therapy medicine.symptom business |
| Zdroj: | Sleep medicine. 15(2) |
| ISSN: | 1878-5506 |
| Popis: | Objectives We aimed to compare post-Pandemrix® vaccination (postvaccine) childhood narcolepsy with cataplexy (NC) vs sporadic pre-H1N1 pandemic (pre-H1N1) cases. Methods Clinical, anthropometric, polysomnographic, and cerebrospinal hypocretin 1 (hcrt-1) measurements were collected together with the video recordings of cataplexy in 27 Finnish patients with NC onset after H1N1 Pandemrix® vaccination (mean age, 12±4years; 52% boys) and 42 Italian NC patients with NC onset before the H1N1 pandemic (mean age, 11±3years; 48% boys). All subjects carried the HLA-DQB1*0602 allele. Results Postvaccine subjects were older at NC onset (12±3 vs 9±3years; P =.008) and displayed a shorter mean sleep latency in multiple sleep latency tests (MSLT) (2.3±2.2 vs 3.7±2.9min; P =.026) compared to pre-H1N1 cases. Anthropometric, clinical (core NC symptoms), hcrt-1 deficiency, and polysomnographic data did not differ among groups, but higher disrupted nocturnal sleep was observed in postvaccine subjects. Comparison of cataplexy features at video assessment showed an overlapping picture with the exception for hyperkinetic movements which appeared to be more evident in pre-H1N1 subjects. Conclusions The clinical picture of childhood NC was similar in postvaccine and pre-H1N1 children. |
| Databáze: | OpenAIRE |
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