Gastrin, somatostatin, G and D cells of gastric ulcer in rats
| Autor: | Yong-Li Yao, Wei Cheng, Tong Zhao, Feng-Peng Sun, Yu-Gang Song |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Somatostatin-Secreting Cells Regulation of gastric function Gastroenterology Internal medicine Gastrins medicine Animals Gastrin-Secreting Cells Stomach Ulcer Enterochromaffin-like cell Rats Wistar Antrum Gastrin Delta cell business.industry digestive oral and skin physiology Radioimmunoassay General Medicine digestive system diseases Rats Disease Models Animal Somatostatin Endocrinology Basic Research Gastric Mucosa G cell business hormones hormone substitutes and hormone antagonists |
| Zdroj: | World journal of gastroenterology. 8(2) |
| ISSN: | 1007-9327 |
| Popis: | AIM: To investigate the relationship among gastrin, somatostatin, G and D cells in gastric ulcer and in its healing process in rats. METHODS: Fourty-nine Wistar rats were divided into 7 groups. The gastric ulcer model was induced by acetic acid successfully. The gastrin and the somatostatin in rat plasma, gastric fluid and antral tissue were measured by radioimmunoassay(RIA). G and D cells in antral mucosa were analyzed with polyclonal antibody of gastrin and somatostatin by immunohistochemical method and Quantimet 500 image analysis system. RESULTS: In gastric ulcer, the level of gastrin in plasma, gastric fluid, and antral tissue increased, that of somatostatin declined, and the disorder gradually recovered to the normal level in the healing process. Immunohistochemical technique of G and D cells in antral mucosa demonstrated that the number of G cells increased and that of D cells decreased, both areas of G and D cells declined, the ratio of number and area of G/D increased in gastric ulcer, and the disorder gradually recovered in the healing process. CONCLUSION: In gastric ulcer, the increased gastrin secreted by G cells, the declined somatostatin secreted by D cells, and the disordered G/D cell ratio can lead to gastrointestinal dysfunction. |
| Databáze: | OpenAIRE |
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