Reduced post-natal versus pre-natal incidence of bent long bones and scapulae in a preliminary investigation using the Han Wistar rat

Autor:	Jane Stewart, Terri Mitchard
Rok vydání:	2014
Předmět:	Male Chondrodystrophy Fetus Incidence (epidemiology) Abnormalities Drug-Induced Physiology Anatomy Biology Osteochondrodysplasias Toxicology medicine.disease Bone and Bones Rats Pre natal Test article Rat fetus Pregnancy medicine Animals Gestation Weaning Female Rats Wistar Maternal-Fetal Exchange
Zdroj:	Reproductive Toxicology. 45:39-44
ISSN:	0890-6238
DOI:	10.1016/j.reprotox.2014.01.001
Popis:	There is a "chondrodystrophy" syndrome in the Han Wistar rat fetus that manifests as characteristic skeletal abnormalities such as bent and/or short long bones, and is classified as permanent detrimental abnormalities (major malformations). This pilot study investigated whether these defects resolve after birth. Han Wistar rats were dosed during organogenesis either with vehicle or test article. Examination of gestation day 20 fetuses showed a slightly increased incidence (11%; 11/101) of skeletal abnormalities in the high dose fetuses compared with 6% (4/67) in control fetuses, whereas no skeletal abnormalities were present in the 205 pups examined on post-natal day 21. The probability of having zero litters containing pups with skeletal abnormalities was p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c99dfa56d1262c7a46091c38a3e3a4 https://doi.org/10.1016/j.reprotox.2014.01.001 Zobrazit plný text záznamu Full Text from ScienceDirect