Management of penile cancer in a Singapore tertiary hospital

Autor: K.T. Chong, Teck Wei Tan, S.J. Chia
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Multivariate analysis
Penile squamous cell carcinoma
BMI
body mass index
NCCN
National Comprehensive Cancer Network
Urology
Inflammatory markers
030232 urology & nephrology
HPV
human papillomavirus
SCC
squamous cell carcinoma
03 medical and health sciences
0302 clinical medicine
Interquartile range
Internal medicine
Epidemiology
Urological cancer
ILND
inguinal lymph node dissection
Medicine
Penile cancer
In patient
Lymph node
IQR
interquartile range
DSNB
dynamic sentinel node biopsy
Gynecology
EAU
European Association of Urology
business.industry
medicine.disease
Diseases of the genitourinary system. Urology
RFS
recurrence-free survival
Surgery
LMR
lymphocyte–monocyte ratio
Dissection
medicine.anatomical_structure
Inguinal
030220 oncology & carcinogenesis
CRP
C-reactive protein
CSS
cancer-specific survival
NLR
neutrophil–lymphocyte ratio
RC870-923
CIS
carcinoma in situ
business
Penis
Oncology/Reconstruction
Zdroj: Arab Journal of Urology
Arab Journal of Urology, Vol 15, Iss 2, Pp 123-130 (2017)
ISSN: 2090-598X
DOI: 10.1016/j.aju.2017.03.001
Popis: Objectives: To present our experience of managing penile squamous cell carcinoma (SCC) in a tertiary hospital in Singapore and to evaluate the prognostic value of the inflammatory markers neutrophil–lymphocyte ratio (NLR) and lymphocyte–monocyte ratio (LMR). Patients and methods: We reviewed our prospectively maintained Institutional Review Board-approved urological cancer database to identify men treated for penile SCC at our centre between January 2007 and December 2015. For all the patients identified, we collected epidemiological and clinical data. Results: In all, 39 patients were identified who were treated for penile SCC in our centre. The median [interquartile range (IQR)] follow-up was 34 (16.5–66) months. Although very few (23%) of our patients with high-risk clinical node-negative underwent prophylactic inguinal lymph node dissection (ILND), they still had excellent 5-year recurrence-free survival (RFS; 90%) and cancer-specific survival (CSS; 90%). At multivariate analysis, higher N stage was significantly associated with worse RFS and CSS. Patients with a high NLR (≥2.8) had significantly higher T-stage (P = 0.006) and worse CSS (P
Databáze: OpenAIRE
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