Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study

Autor: Julian Hackler, Hajo Haase, Matthias B. Schulze, Fabian Eichelmann, Johannes F. Kopp, Tanja Schwerdtle, Wiebke Alker, Lutz Schomburg, Olga Kuxhaus, Anna P. Kipp, Maria Cabral
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
medicine.medical_specialty
Colorectal cancer
type 2 diabetes mellitus
Medicine (miscellaneous)
chemistry.chemical_element
trace elements
colorectal cancer
Type 2 diabetes
Gastroenterology
Cohort Studies
03 medical and health sciences
Selenium
0302 clinical medicine
cardiovascular disease
Internal medicine
medicine
Humans
Prospective Studies
Prospective cohort study
Nutrition and Dietetics
business.industry
Incidence (epidemiology)
Selenoprotein P
Incidence
Trace elements
Prospective study
Type 2 diabetes mellitus
Cardiovascular disease
Original Contribution
medicine.disease
030104 developmental biology
chemistry
Diabetes Mellitus
Type 2
Cardiovascular Diseases
030220 oncology & carcinogenesis
Cohort
business
Colorectal Neoplasms
Copper
600 Technik
Medizin
angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Cohort study
prospective study
Zdroj: European Journal of Nutrition
European journal of nutrition, 2021:2494
DOI: 10.14279/depositonce-17227
Popis: Purpose We aimed to examine the prospective association between manganese, iron, copper, zinc, iodine, selenium, selenoprotein P, free zinc, and their interplay, with incident type 2 diabetes (T2D), cardiovascular disease (CVD) and colorectal cancer (CRC). Methods Serum trace element (TE) concentrations were measured in a case-cohort study embedded within the EPIC-Potsdam cohort, consisting of a random sub-cohort (n = 2500) and incident cases of T2D (n = 705), CVD (n = 414), and CRC (n = 219). TE patterns were investigated using principal component analysis. Cox proportional hazard models were fitted to examine the association between TEs with T2D, CVD and CRC incidence. Results Higher manganese, zinc, iodine and selenium were associated with an increased risk of developing T2D (HR Q5 vs Q1: 1.56, 1.09–2.22; HR per SD, 95% CI 1.18, 1.05–1.33; 1.09, 1.01–1.17; 1.19, 1.06–1.34, respectively). Regarding CVD, manganese, copper and copper-to-zinc ratio were associated with an increased risk (HR per SD, 95% CI 1.13, 1.00–1.29; 1.22, 1.02–1.44; 1.18, 1.02–1.37, respectively). The opposite was observed for higher selenium-to-copper ratio (HR Q5 vs Q1, 95% CI 0.60, 0.39–0.93). Higher copper and zinc were associated with increasing risk of developing CRC (HR per SD, 95% CI 1.29, 1.05–1.59 and 1.14, 1.00–1.30, respectively). Selenium, selenoprotein P and selenium-to-copper-ratio were associated to decreased risk (HR per SD, 95% CI 0.82, 0.69–0.98; 0.81, 0.72–0.93; 0.77, 0.65–0.92, respectively). Two TE patterns were identified: manganese–iron–zinc and copper–iodine–selenium. Conclusion Different TEs were associated with the risk of developing T2D, CVD and CRC. The contrasting associations found for selenium with T2D and CRC point towards differential disease-related pathways.
Databáze: OpenAIRE
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